Amrinone lactate

Amrinone lactate is physically and chemically incompatible with alkaline solutions. Pharmaceuticals that are incompatible include digoxin, potassium chloride, procainamide hydrochloride, propranolol hydrochloride, verapamil hydrochloride, sodium chloride, and glucose solutions containing frusemide.101 

Aqueous solutions of captopril are prone to oxidative degradation this increases with an increase in pH above 4. There are reports of variations in stability of captopril solutions, depending on the formulation. Addition of sodium ascorbate increases stability of the aqueous solution made of captopril powder. 

Diltiazem hydrochloride degrades to desacetyldiltiazem, and this was enhanced at acidic pH and elevated temperatures.102 

Digitoxin potentially adsorbs onto glass, plastic, and inline intravenous filters containing cellulose ester membranes, some aqueous solutions such as 5% glucose, or 0.9% sodium chloride. The loss in potency may be minimized by pretreatment of the filter with a polymer coating. Such losses in potency were not found with 30% alcohol solutions.103104 

Dobutamine is unstable with alkaline preparations and is incompatible with sodium bicarbonate 5% and alkaline drugs such as aminophylline, frusemide, thiopentone sodium, heparin, bumetanide, calcium gluconate, insulin, diazepam, and phenytoin.105,106 

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