Amplification technology for

One of the barriers to the spread of rapid amplification technology for POC clinical use is the cost of the instrumentation, which limits the use of the technology. To make biosensor technology more accessible, recently a manuscript was published (38) describing an inexpensive array biosensor. Here we describe a simple and inexpensive battery-powered thin-film... 

In the past few years, erbium doped materials gained much attention in the field of optical communications, since the Er ion shows a broad optical emission at 1540 nm [111], within the main wavelengths window in the telecommunication technology. For this reason Er can be suitable as an active element for the generation and amplification of light in optical devices [112,113], also if limitations for the realization of an efficient planar amplifier are related to the small cross section for Er excitation (typically 10 -10 cm according to the matrix). In order to enhance Er ion pumping efficiency, a possible... 

In summary, bDNA has a number of distinct theoretical and practical advantages over target amplification systems for direct quantitation of specific nucleic acid sequences. The following sections review the specific clinical and research applications of this technology. 

S. Ekstrom, D. Ericsson, P. Onnerfjord, M. Bengtsson, J. Nilsson, G. Marko-Varga, and T. Laurell. Signal Amplification Using Spot-on-a-Chip Technology for the Identification of Proteins via MALDI-TOF MS. Anal. Chem., 73(2001) 214-219. 

Nygaard V, Hovig E. Options available for profiling small samples a review of sample amplification technology when combined with microarray profiling. Nucleic Acids Res 2006 34 996-1014. 

Microarray analysis can also be applied to the study of multiple tissue specimens with tissne microarrays (Rimm, D.L., Camp, R.L, Charette, L.A. et al., Tissne microarray a new technology for amplification of tissue resources, Cancer J. 7, 24-31, 2001 Bubendorf, L., Nocito, A., Moch, K., and Santer, G., Tissne microarray [TMA] technology minaturized pathology archives for high-thronghput in situ stndies, J. Pathol. 195,72-79,2001 Fedor, H.L. and De Marzo, A.M., Practical methods for tissue microarray construction. Methods Mol. Biol. 103, 89-101, 2005). 

Saldanha J, Lelie N, Heath A. Establishment of the first international standard for nucleic acid amplification technology (NAT) assays for HCV RNA. WHO Collaborative Study Group. Vox Sang 1999 76 149-58. 

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