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Amphotericin B lipid complex Abelcet

Lipid-associated formulations of amphotericin B, liposomal amphotericin B (AmBisome) and amphotericin B lipid complex (Abelcet) have been approved for use in proven cases of candidiasis however, patients with invasive candidiasis have also been treated successfully with amphotericin B colloid dispersion (Amphotec or Amphocil). The lipid-associated formulations are less toxic but as effective as amphotericin B deoxycholate. [Pg.435]

Amphotericin B (Amphocin) Amphotericin B Cholesteryl (Amphotec) Amphotericin B Lipid Complex (Abelcet) Amphotericin B Liposomal (AmBisome) Anidulafungin (Eraxis)... [Pg.36]

Suspension for Injection-. 5 mg/ml (Amphotericin B lipid complex, Abelcet). [Pg.73]

Ringden O, Jonsson V, Hansen M, ToUemar J, Jacobsen N. Severe and common side-effects of amphotericin B lipid complex (Abelcet). Bone Marrow Transplant 1998 22(7) 733. ... [Pg.207]

Husain S, Capitano B, Corcoran T, Studer SM, Crespo M, Johnson B, Pilewski JM, Shutt K, Pakstis DL, Zhang S, Carey ME, Paterson DL, McCurry KR, Venkataramanan R. Intrapulmonary disposition of amphotericin B after aerosolized delivery of amphotericin B lipid complex (Abelcet ABLC) in lung transplant recipients. Transplantation 2010 90(11) 1215-9. [Pg.435]

Currently, toxic effects of AmB have been largely ameliorated with the advent of lipid formulations, in these formulations, deoxycholate has been replaced by other Upids that mask AmB from susceptible tissues, thus reducing toxicity and facilitating its preferential uptake by reticuloendothelial cells. Thus, this drug delivery results in increasing efficacy and reduced toxicity. Three Upid-associated formulations of amphotericin are commercially available Uposomal amphotericin B (AmBisome), amphotericin B lipid complex (Abelcet), and amphotericin B colloidal dispersimi (Amphocil). These compoimds have been considered between the most striking advances in Leishmania therapy [52],... [Pg.4435]

Adedoyin, A., C.E. Swenson, L.E. Bolcsak, A. Hellmann, D. Radowska, G. Horwith, A.S. Janoff, and R.A. Branch, A pharmacokinetic study of amphotericin B lipid complex injection (Abelcet) in patients with definite or probable systemic fungal infections. Antimicrob Agents Chemother, 2000.44(10) 2900-2. [Pg.376]

Adedoyin A, Bernardo JF, Swenson CE, Bolsack LE, Horwith G, DeWit S, Kelly E, Klasterksy J, ScuUer JP, DeValeriola D, Anaissie E, Lopez-Berestein G, Llanos-Cuentas A, Boyle A, Branch RA. Pharmacokinetic profile of ABELCET (amphotericin B lipid complex injection) combined experience from phase I and phase II studies. Antimicrob Agents Chemother 1997 41(10) 2201-8. [Pg.206]

The use of deoxycholate amphotericin B frequently is associated with the development of induced nephrotoxicity. In an attempt to decrease the incidence of nephrotoxicity, three lipid formulations of amphotericin B have been developed and approved for use in humans amphotericin B lipid complex (ABLC, Abelcet Enzon Pharmaceuticals), amphotericin B colloidal dispersion (ABCD, Amphotec Inter-mune Pharmaceuticals), and liposomal amphotericin B (AmBisome Gilead Pharmaceuticals). In these preparations, amphotericin B is incorporated into the phospholipid bilayer membrane rather than in the enclosed aqueous phase. [Pg.2185]

Amphotericin B is complexed with deoxycholate (C-AMB) and marketed as a lyophilized powder (fungizone) containing 50 mg of amphotericin B that forms a colloid in water. Three lipid formulations of amphotericin B are marketed in the U.S. Amphotericin B colloidal dispersion (ABCD, AMPHOTEC, amphocil) contains equimolar amounts of amphotericin B and cholesteryl sulfate. AMBISOME is a small, unilamellar vesicle formulation that combines amphotericin B (50 mg) with 350 mg of lipid (phosphatidylcholine, cholesterol, and distearoylphosphatidylglycerol, in molar ratio of 10 5 4) in an -10% molar ratio. Amphotericin B lipid complex (ABLC, abelcet) contains dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol in a 7 3 mixture with -35 mol% of amphotericin B. [Pg.798]

Abelcet Amphotericin B lipid complex 120-500 mg in an infusion bag/bottle 500 mL... [Pg.284]

There are relatively few examples of human exposure to intravenous administration of solid fine-particle active agents. Several particle-based products for intravenous injection are currently available in the United States these include Ambisome (Astellas Pharma US, Inc.), which is a liposomal formulation of amphotericin B Abelcet (Enzon Pharma, Inc.), an amphotericin B lipid complex Doxil (Tibotec), a liposomal formulation of doxorubicin hydrochloride and Abraxane (American Bioscience, Inc.), a paclitaxel product in which the active agent molecnles are protein bound. The particles in liposome and lipid complexes are generally not rigid solid particles, and the protein-bound paclitaxel particles are also expected to be deformable. [Pg.81]

Abelcet . This is a sterile aqueous suspension of a lipid-amphotericin B complex. Each 20 mL vial contains 100 mg amphotericin B, 30 mg/L a-cfimyristoylphospha-tidylglycerol, 68 mg/L a-dunyristoylphosphatidylcholine. Adult dose 5 mg/l daily. [Pg.500]


See other pages where Amphotericin B lipid complex Abelcet is mentioned: [Pg.1462]    [Pg.75]    [Pg.75]    [Pg.75]    [Pg.1462]    [Pg.75]    [Pg.75]    [Pg.75]    [Pg.265]    [Pg.112]    [Pg.3362]    [Pg.1643]    [Pg.335]   
See also in sourсe #XX -- [ Pg.75 ]

See also in sourсe #XX -- [ Pg.75 ]

See also in sourсe #XX -- [ Pg.75 ]




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