Probenecid Amoxicillin

Ncfsse.nfj g onorriioene amoxicillin (+ probenecid) or a quiiiolone spectinomycin or cefixime or cefotaxime... 

Prepubertal children (> 2 years of age) 50 mg/kg amoxicillin combined with 25 mg/kg probenecid as a single dose... 

T effects W probenecid, disulfiram, T risk of rash W/ allopurinol, effects OF OCP, effects W/ tetracyclines, chloramphenicol EMS See Amoxicillin Amphotericin B (Amphecin) [Antifungal/Pelyene Macrolide]... 

Except for oral amoxicillin, penicillins should be given 1-2 hours before or after a meal they should not be given with food to minimize binding to food proteins and acid inactivation. Blood levels of all penicillins can be raised by simultaneous administration of probenecid, 0.5 g (10 mg/kg in children) every 6 hours orally, which impairs renal tubular secretion of weak acids such as 3-lactam compounds. 

Uncomplicated anogenital infections amoxicillin with probenecid by mouth spectinomycin i.v., cefotaxime i.m. or ciprofloxacin by mouth may be used for penicillin-allergic patients. 

In healthy subjects probenecid completely blocked the renal secretion of the active metabolite of oseltamivir after oral administration, increasing its AUC 2.5 times (20). In vitro studies of the metabolite on the human renal organic anionic transporter I (hOATl) were investigated in Chinese hamster ovary cells stably transfected with the transporter. The metabolite was a low-efficiency substrate for hOATl and a very weak inhibitor of hOATl-mediated transport of pora-aminohippuric acid. Probenecid inhibited the transport of the metabolite, pora-aminohippuric acid, and amoxicillin via hOATl. 

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

Erythromycin suspension 50 mg/kg/d p.o. in four divided doses for 14 days) Erythromycin suspension 50 mg/kg/d p.o. in four divided doses for 14 days Acute epididymo-orchitis Amoxicillin 3.0 g p.o., or ampicillin 3.5 g p.o., or aqueous procaine penicillin G 4.8 million units IM at two sites (each along with probenecid 1.0 g p.o.), or spectinomycin 2.0 g IM or ceftriaxone 250 mg IM followed by tetracycline 500 p.o. four times daily for 10 days or... 

Probenecid inhibits the renal secretion of the active metabolite of oseltamivir and marked raises its plasma levels, but this is not clinically relevant because of the wide safety margin of oseltamivir. There was no pharmacokinetic interaction between amoxicillin and oseltamivir, and cimetidine did not alter oseltamivir pharmacokinetics. 

Probenecid appears to completely inhibit the renal tubular secretion of the active metabolite of oseltamivir via the anionic renal transporter process. Oseltamivir does not alter amoxicillin pharmacokinetics, suggesting minimal potential to inhibit the renal anionic transport process. Cimetidine, which inhibits the renal tubular secretion of drugs via the cationic secretion transport process, had no effect on oseltamivir. 

Probenecid markedly increased the AUC of the active metabolite of oseltamivir, but because of the large safety margin of oseltamivir, this increase is not considered to be clinically relevant. " Oseltamivir did not alter amoxicillin pharmacokinetics, and is therefore unlikely to interact with other renally secreted organic acids. Other drugs that are involved in the active anionic tubular secretion mechanism are also unlikely to interact. Cimetidine does not interact with oseltamivir, and other drugs that are inhibitors of the renal cationic secretion transport process are unlikely to interact. ... 

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