Amoxicillin dosage

Hoffman, A., et al. 1998. Pharmacodynamic and pharmacokinetic rationales for the development of an oral controlled-release amoxicillin dosage form. J Control Release 54 29. 

A physician prescribes Amoxil (amoxicillin) oral pediatric suspension for a patient to be taken in doses of 1/2 teaspoonful four times a day for seven days. How many milliliters of the suspension should be dispensed to provide the quantity for the prescribed dosage regimen ... 

Amoxicillin is a close analogue to ampicillin that is also inactivated by -lactamases. The action and uses of amoxicillin are like those of ampicillin. Hence it is used against a wide variety of bacterial infections in farm animals including those of the gastrointestinal, respiratory, urinary, and mammary system. It is administered in the form of tablets, suspensions, powders, parenteral, and intramammary formulations at dosage rates of 10 mg/kg bw by the oral route and 7-15 mg/kg bw by the parenteral route. 

A 48-year-old woman with pneumococcal meningitis developed acute oliguric renal insufficiency after taking high-dose amoxicillin (320 mg/kg/day) for 4 days. Amoxicillin crystallization was documented by infrared spectrometry. The outcome was favorable after dosage reduction, a single hemodialysis, and adequate hydration. 

Whitehead L, Collett JH, Fell JT. Amoxicillin release from a floating dosage form based on alginates. Int J Pharm 2000 210 45 9. 

The US Pharmacopoeia gives an HPLC method for assay of the drug substance and for amoxicillin content in various dosage forms [9], A different HPLC method is specified for amoxicillin content in co-formulation products with potassium clavulanate [56],... 

Seikel K, Shelton S, McCracken G. Middle ear fluid concentrations of amoxicillin after large dosages in children with acute otitis media. Pediatr Infect DisJ 1997 16 710-711. 

Cefadroxil has an amoxicillin-like side chain at C-7 and is orally active. There are some indications that cefadroxil has some immunostimulant properties mediated through T-cell activation and that this is of material assistance to patients in fighting infections. The prolonged biological half-life of cefadroxil allows once-a-day dosage. 

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