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Ammonium structure

The spectral changes associated with the protonatiop of p -dimethylamino-derivatives [45] contrast sharply with those described above. There is a hypsochromic shift of the maximum absorption and the absorption spectrum of the conjugate acid of benzylidene-p -dimethylaminoaniline is closely similar to that of benzylideneaniline free base, which leads to the conclusion that the monocation has the ammonium structure. The conjugate acid of benzylidene-p -dimethylaminoaniline shows, however, an additional peak at 455 nm, which was ascribed to the anilium form, but the position of the tautomeric equilibrium could not be determined without the knowledge of the extinction coefficients of the two forms, p/fj-values of only a few of these compounds were estimated from these measurements on flowing solutions. So, for example, p-trimethylammonium-benzylidene-p-toluidine has a p/La-value of 1 85, and for variable p -substituents a p-constant of T5 has been calculated. The p -dimethylamino group may be expected to have p/fa in excess of 5. [Pg.309]

In determinations of the structure of the protonation products of enamines IR spectroscopy is very helpful N-protonation to the ammonium structure (6) should lead to N—H valence and N—H deformation vibrations which are both absent in the experimental IR spectrum of immonium salts of enamines. Consequently, these C-protonation products (7) show strong C=N vibration bands in the region of 1644 to 1691 cm which are shifted hypsochromically by 7-69 cm" from the C=C vibration of corresponding enamines. For example, the perchlorate of protonated 247b shows a C=N vibration at 1686 cm "S which is 36cm" higher than that of the parent enamine. On the contrary,, y-unsaturated allylamines show no shift of their C=C vibration on protonation ... [Pg.74]

Topical miotic agents are historically important glaucoma medications but are less commonly used today. Miotics lower lOP by causing muscarinic-induced contraction of the ciliary muscle, which facilitates aqueous outflow. They do not affect aqueous production. Multiple miotic agents have been developed. Pilocarpine and carbachol are cholinomimetics that stimulate muscarinic receptors. Ecbotbiopbate (Phospholine iodide) is an organophosphate inhibitor of acetylcholinesterase it is relatively stable in aqueous solution and, by virtue of its quaternary ammonium structure, is positively charged and poorly absorbed. The usefulness of these medicines is lessened by their numerous side effects and the need to use them three to four times a day. [Pg.212]

Due to their poor lipophilic properties, compounds with a quaternary ammonium structure are poorly absorbed after oral administration. Thus, central effects generally lack, because these alkaloids do not readily cross the blood-brain barrier. Similarly, quaternary ammonium compounds do... [Pg.738]

The model described by Geiger et al. is consistent with conclusions of Larson et al. [60], who, on the basis of molecular orbitals (MO) calculations, tried to explain why benzyl acetates and halides undergo heterolysis from T, and benzyl-ammonium structures from Sj. They found that immediately before dissociation, as the C-X bond elongates, the state rapidly approaches the ncr state in the case of acetates and halides and in the case of ammonium salt because there is no lone pair of electrons in the latter structure. It was suggested that an efficient spin inversion process leads to ion pair formation from the nci state, and no such channel for the cnr state exists. [Pg.8]

Ohtani et al. used polystyrene-supported ammonium fluoride as a phase transfer catalyst (triphase catalysis) for several base-catalyzed reactions, such as cyanoethylation, Knoevenage reaction, Claisen condensation and Michael addition. The catalytic activity of the polystyrene-supported ammonium fluid was comparable to that of tetrabutylammonium fluoride (TBAF). The ionic loading and the ammonium structure of the fluoride polymers hardly affected the catalytic efficiency. The reaction was fast in a non-polar solvent (e.g., octane or toluene) from which the rate-determining step of the base-catalyzed reaction is very similar to that of the nucleophilic substitution reactions. [Pg.830]


See other pages where Ammonium structure is mentioned: [Pg.73]    [Pg.309]    [Pg.658]    [Pg.658]    [Pg.380]    [Pg.248]    [Pg.145]    [Pg.206]    [Pg.87]    [Pg.225]    [Pg.271]    [Pg.74]    [Pg.87]    [Pg.273]    [Pg.658]    [Pg.316]    [Pg.566]    [Pg.182]    [Pg.109]    [Pg.562]    [Pg.319]    [Pg.846]    [Pg.145]    [Pg.363]    [Pg.249]    [Pg.154]    [Pg.332]    [Pg.16]   
See also in sourсe #XX -- [ Pg.426 ]




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Ammonium chloride structure

Ammonium chloride, crystal structure

Ammonium crystal structure

Ammonium esters, structural properties

Ammonium halides, structure

Ammonium iodide, crystal structure

Ammonium ion structure

Ammonium salts structure

Ammonium salts, chiral structures

Crystal structure ammonium salts

Methylated ammonium compounds structures

The Structure of Bases Obtained from Heterocyclic Quaternary Ammonium Salts

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