Benazepril Amlodipine

ACE inhibitor with calcium Amlodipine/benazepril (Lotrel) 2.5/10, 5/10, 10/20 1... 

Amlodipine, benazepril, captopril, enalapril, felodipine, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, losartan... 

Jamerson et al Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl 3 Med 2008 359 2417. [PMID 19052124]... 

Dosage Dose should be individualized by titration 180 mg/d with upward titrations if adequate response is not obtained Dose should be individualized 5 mg/d with a maximum dose of 10 mg/d Dose should be individualized by titration 2.5 mg to 5 mg amlodipine and 10 mg to 20 mg of benazepril once daily... 

Note Lotrel is benazepril and amlodipine Lotensin-HCT is benazepril and hydrochlorothiazide... 

Calcium channel blockers can be combined with ACE inhibitors. Such combinations include benazepril with amlodipine (Lotrel), enalapril with diltiazem (Teczem), enalapril with felodipine (Lexxel), and trandolapril with verapamil (Tarka). 

A study in 12 healthy subjects indicated that there was no pharmacokinetic interaction between single doses of amlodipine 5 mg and benazepril 10 mg. ... 

Sun JX, Cipriano Chan K, John VA. Pharmacokinetic interaction study between benazepril and amlodipine in healtiiy subjects. EurJ Clin Pharmacol (1994) 47,285-9. 

While each of these was a therapeutic use randomized clinical trial, the designs of the trials differed such that the most appropriate control treatment was employed in each case to best answer the research question of interest (Turner and Hoofwijk 2013). SHEP was a multicenter, randomized, double-blind, placebo-controlled trial of chlorthalidone for isolated systolic hypertension. ALLHAT employed a multicenter, randomized, double-blind, active-controlled design to compare chlorthalidone with each of three alternative antihypertensive treatments with regard to the incidence of nonfatal myocardial infarction and fatal coronary heart disease in hypertensive patients with at least one other risk factor for coronary heart disease. ACCOMPLISH was also a multicenter, randomized, double-blind, active-controlled clinical trial, but one that differed from ALLHAT in that a combination therapy comprising benazepril plus amlodipine was compared with benazepril plus hydrochlorothiazide with regard to reduction of cardiovascular events in high-risk hypertensive patients (Turner and Hoofwijk 2013). 

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