Benazeprilate

Hydroserpine 2 Tablets—hydrochbrothiazide, reserpine Hyzaar—hydrochlorothiazide, losartan potassium Inderide—hydrochlorotliiazide, propranolol HC1 Inderide LA—hydrochlorotliiazide, propranolol HC1 Lexxel Extended-Release—enalapril maleate, felodipine Lopressor—hydrochlorothiazide, metoprolol Lotensin HCT—hydrochlorothiazide, benazepril Lotrel—amlodopine, benazepril... 

C,4H, N203 86499-52-7) see Benazepril ethyl (Z)-2-(2-aminathiazol-4-yl)-2-hydroxyiminoacetate (C7H(,N303S 64485-82-1) see Carumonam Ceftazidime ethyl 2-(2-amino-4-thiazolyl)-2(Z)-hydFoxyiminoacetate... 

Benazepril Docetaxel Fluazacort Imiquimod Irbesartan Midodtine Oseltamivir Paclitaxel Pemirolast Pranlukast Tazanolast Tranylcypromine Zanamivir Zidovudine sodium benzenesultinate... 

KKH Chan, A Buch, RD Glazer, VA John, WH Barr. Site-differential gastrointestinal absorption of benazepril hydrochloride in health volunteers. Pharmaceut Res 11 432-437, 1994. 

Some developments have been carried out for the enantioselective synthesis of biologically active compounds. One such example is the synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate, an important intermediate for the angiotensinconverting enzyme (ACE) inhibitor benazepril, or for coenzyme A, using the NORPHOS ligand (Scheme 33.9) [21]. 

Scheme 33.9 Enantioselective hydrogenation with Rh-NOR-PHOS complex as a key step in the synthesis of the ACE inhibitor benazepril (see Table 33.2).

Belt-conveyor scales, 26 244—245 Belt filter press, 25 913 Belt saponification, in vinyl alcohol polymerization, 25 609-610 Benard instability, 11 764 Benazepril hydrochloride, molecular formula and structure, 5 149t Benchmark dose and margin-of-exposure method, 25 244... 

In vitro studies were also conducted to discover the enzymes responsible for bioactivation of benazepril. With different preparations and eserine as an inhibitor, the involvement of arylesterases (EC 3.1.1.2) and cholinesterases (EC 3.1.1.8) was ruled out, while that of carboxylesterases (EC 3.1.1.1) was... 

Undesired effects. The magnitude of the antihypertensive effect of ACE inhibitors depends on the functional state of the RAA system. When the latter has been activated by loss of electrolytes and water (resulting from treatment with diuretic drugs), cardiac failure, or renal arterial stenosis, administration of ACE inhibitors may initially cause an excessive fall in blood pressure. In renal arterial stenosis, the RAA system may be needed for maintaining renal function and ACE inhibitors may precipitate renal failure. Dry cough is a fairly frequent side effect, possibly caused by reduced inactivation of kinins in the bronchial mucosa. Rarely, disturbances of taste sensation, exanthema, neutropenia, proteinuria, and angioneurotic edema may occur. In most cases, ACE inhibitors are well tolerated and effective. Newer analogues include lisinopril, perindo-pril, ramipril, quinapril, fosinopril, benazepril, cilazapril, and trandolapril. 

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