Amitriptyline chloride

SYNS AMITID AMITRIL AMITRIPTYLINE CHLORIDE AMITRYPTYLINE HYDROCHLORIDE DAMILEN HYDROCHLORIDE DEPREX 10,11-DIHYDRaN,N-DIMETHYL-5H-DIBENZO(a,d)-CYCLOHEPTENE-AS.LpropyLAXHNE HCL 3-(3-DIMETHYLAMINOPROPYLIDENE)-l 2-4 5-... 

Amitriptylin oxide 3-(Dimethylamino) propyl chloride Amitriptyline HCI Ch/orprothixene Clomipramine Cyclobenzaprine Imipramine HCI Oxetorone fumarate Prothipendyl HCI... 

Grignard gives the tertiary alcohol after hydrolysis. Reaction of the alcohol with hydrochloric acid proceeds with rearrangement and opening of the strained cyclopropane to give a chloride. Sn2 displacement of the chloride with dimethylamine forms amitriptyline. Alternatively, dibenzosuberone can be reacted with dimethylaminopropyl Grignard to form an alcohol, which upon dehydration forms amitriptyline. 

C2H7N 124-40-3) see Alininoprofen Alpidem Altretamine Amitriptyline Benzalkonium chloride ... 

When a dmg is in its unionised form it will more readily diffuse from the urine to the blood. In an acidic urine, acidic drugs will diffuse back into the blood from the urine. Acidic compounds such as nitrofurantoin are excreted faster when the urinary pH is alkaline. Amfetamine, imipramine and amitriptyline are excreted more rapidly in acidic urine. The control of urinary pH in studies of pharmacokinetics is thus vital. It is difficult, however, to find compounds to use by the oral route for deliberate adjustment of urinary pH. Sodium bicarbonate and ammonium chloride may be used but are unpalatable. Intravenous administration of acidifying salt solutions presents one approach, especially for the forced diuresis of basic dmgs in cases of poisoning. 

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