Aminopyrine breath test

The structural feature of aminopyrine is similar to antipyrine except that aminopyrine has a substituent (dimethylamino group) at the C-4 position (Fig. 4). The exceptional efficacy of the aminopyrine breath test derives from the presence of multiple N-methyl groups that are readily removed by oxidative N-demethyla-tion. Hence, further oxidation of several formaldehyde molecules produced by demethylation of aminopyrine gives large volumes of labeled COj that is readily quantified. Some of the metabohtes of aminopyrine are given in Fig. 4 [30, 85, 87-90]. 

Schoeller DA, Kotake AN, Lambert GH, et al. Comparison of the phenacetin and aminopyrine breath tests effect of liver disease, inducers and cobaltous chloride. Hepatology 1985 5 276-281. 

Giannini E, Fasoli A, Chiarbonello B, et al. (2002) 13C-aminopyrine breath test to evaluate severity of disease in patients with chronic hepatitis C virus infection. Aliment Pharmacol Ther 16 717-725. 

Villeneuve JP, Infante-Rivard C, Ampelas M, et al. (1986) Prognostic value of the aminopyrine breath test in cirrhotic patients. Hepatology 6 928—931. 

Monroe, P.S., Baker, A.L., Schneider, J.F., Krager, P.S., Klein, PJ>., Schoeller, D. The aminopyrine breath test and serum bile acids reflect histologic severity in chronic hepatitis. Hepatology 1982 2 317-322... 

Urbain, D., Muls, V., Thys, O., Ham, H.R. Aminopyrine breath test improver long-term prognostic evaluation in patients with alcoholic cirrhosis in Child class A and B. J. Hepatol. 1995 22 179-183... 

Perri F, Pasture M, Annese V, AndriuUi A, The aminopyrine breath test. Ital J Gastroenterol 1994 26 306-17. 

The [-aminopyrine breath test, a comparison of different forms of analysis. Br. J. din. Pharmac. 8 539-545. 

Another application of " C-labelled compounds is their use as substrates for the evaluation of hver function. In this case, the labelled position is veiy important for the determination of the enzymatic mechanism involved. Results obtained from the aminopyrine breath test, an example of this type of application, will be presented. 

Clearance tests of liver function assess a number of physiologic activities including hepatic uptake, hepatic metabolism, and hepatic excretion. Typical clearance tests of liver function include indocyanine green (ICG), antipyrine clearance test and C aminopyrine breath test. These tests give an estimation of the ability of the liver to extract and detoxify exogenous toxins (xenobiotics). Measuring the excretion of endogenously produced serum bile acids is an additional measure of hepatic clearance and has been used as a sensitive measure of early solvent hepatotoxicity." "... 

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