Aminomethylation trans

AMNES-CYCLOALIPHATIC AMINES] (Vol 2) trans-l,3-Di(aminomethyl)cydohexane [10339-97-6]... 

Chemical Name trans-4-(aminomethyl)cyclohexanecarboxylic acid Common Name —... 

Pyrrolidines have been prepared by 1,3-dipolar cycloaddition of N-(benzyli-dene)trimethylsilylamine/TMSOf 20 and methyl acrylate, N-methylmaleimide, or dimethyl maleate [35]. More recently, methyl trans-3-cyanociruiamate 1479 was reacted with N-benzyl-N-(trimethylsilylmethyl)aminomethyl methyl ether 1480 and trifluoroacetic acid in CH2CI2 at 0°C and 24°C to afford, via 1481, the pyrrolidine derivative 1482 in high yield and MeOSiMe3 13a [35a] (Scheme 9.20). Several... 

Diaminodiphenyl sulfone (DDS), 10 454 cis -1,3 -D i( aminomethyl)cyclohexane, physical properties of, 2 500t MS-l,4-Di(aminomethyl)cyclohexane, physical properties of, 2 500t MS,tra s-l,3-Di(aminomethyl)cyclohexane, physical properties of, 2 500t MS,tra s-l,4-Di(aminomethyl)cyclohexane, physical properties of, 2 500t trans -1,3 -D i( aminomethyl)cyclo hexane, physical properties of, 2 500t... 

In the reactions of cis- and rrans-2-aminomethyl-l-cyclohexanol or -1-cycloheptanol or cis- and trans-2-hydroxymethyl-l-cyclohexylamine or -1-cycloheptylamine with ethyl 4-chlorobenzimidate, the stereo- and regio-isomeric derivatives and homologs 164 and 165 were prepared (79T799). The amidine intermediate 166 of the benzimidate ring closure was also... 

Later, Tieke reported the UV- and y-irradiation polymerization of butadiene derivatives crystallized in perovskite-type layer structures [21,22]. He reported the solid-state polymerization of butadienes containing aminomethyl groups as pendant substituents that form layered perovskite halide salts to yield erythro-diisotactic 1,4-trans polymers. Interestingly, Tieke and his coworker determined the crystal structure of the polymerized compounds of some derivatives by X-ray diffraction [23,24]. From comparative X-ray studies of monomeric and polymeric crystals, a contraction of the lattice constant parallel to the polymer chain direction by approximately 8% is evident. Both the carboxylic acid and aminomethyl substituent groups are in an isotactic arrangement, resulting in diisotactic polymer chains. He also referred to the y-radiation polymerization of molecular crystals of the sorbic acid derivatives with a long alkyl chain as the N-substituent [25]. More recently, Schlitter and Beck reported the solid-state polymerization of lithium sorbate [26]. However, the details of topochemical polymerization of 1,3-diene monomers were not revealed until very recently. 

Dossing, A. Toftlund, H. Hazell, A. Bourassa, J. Ford, P. C. Crystal structure, luminescence and other properties of some lanthanide complexes of the polypyridine ligand 6,6,-bis[bis(2-pyridylmethyl)aminomethyl]-2,2,-bipyridine. J. Chem. Soc., Dalton Trans. 1997, (3), 335-339. 

In the course of the catalytic hydrogenation of a,us dinitriles over Raney nickel, by-products are obtained from C-N and C-C bond formation. The mechanism of the formation of these compounds was investigated. Cyclic and linear secondary amines can result from the same secondary imine through a transimination process involving a ring-chain tautomerism. Stereochemical results for 2-aminomethyl-cyclopentylamine (AMCPA) are in accordance with a specific cyclisation pathway favored by an intramolecular hydrogen bond giving rise to the cis isomer from aminocapro-nitrile, unfavored in the case of adiponitrile which leads to the trans AMCPA as the major isomer. 

Hug GL, Bonifacic M, Asmus K-D, Armstrong DA (2000a) Fast decarboxylation of aliphatic amino adds induced by 4-carboxybenzophenone triplets in aqueous solutions. A nanosecond laser flash photolysis study. J Phys Chem B 104 6674-6682 Hug GL, Carmichael I, Fessenden RW (2000b) Direct EPR observation of the aminomethyl radical during the radiolysis of glycine. J Chem Soc Perkin Trans 2 907-908 Hunter EPL, DesrosiersMF, Simic MG (1989) The effect of oxygen, antioxidants and superoxide radical on tyrosine phenoxyl radical dimerization. Free Rad Biol Med 6 581-585 Ito O (1992) Flash photolysis study for reversible addition reactions of thiyl radicals with olefins and acetylenes. Trends Phys Chem 3 245-266... 

Denda et al. previously demonstrated40 that tran.s-4-aminomethyl cyclohexane carboxylic acid (/-AMCIIA), an anti-fibrinolytic agent that activates plasminogen, improved the barrier homeostasis and whole skin condition. After barrier disruption, proteolytic activity in the epidermis increased within 1 to 2 h. This increase was inhibited by t-AMCHA. Topical application of r-AMCHA or... 

Denda, M., Kitamura, K., Elias, P.M., and Feingold, K.R. trans-4-(Aminomethyl)cyclohexane carboxlic acid (T-AMCHA), and anti-fibrinolytic agent, accelerates barrier recovery and prevents the epidermal hyperplasia induced by epidermal injury in hairless mice and humans. J. Invest. Dermatol. 109, 84—90 (1997). 

BBBAN = 2,7-bis-l,8-2-naphthyridine BEAN = 2,7-bis-(V,Ai -diethylaminomethyl)-l,8-naphthyridme BPMAN = 2,7-bis[bis(2-pyridylmethyl)aminomethyl]-1,8-naphthyri-dine BPMCN = AJ,AJ -bis(2-pyridylmethyl)-AJ,V -dimethyl-trans-l,2-diaminocyclohexane dxlC02H = 2,6-Bis[(2,6-dimethylphenyl)methyl]-4-tgrt-butylbenzoic acid ENDOR =... 

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