Aminocarboxylic acids acid anhydrides

In principle, the reactions employed to bring about peptide formation between an (aminoalkyl)phosphonic acid and an aminocarboxylic acid are similar to those used in conventional peptide chemistry. Thus, a diester of the (aminoalkyl)phosphonic acid is brought into contact with the A-protected aminocarboxylic acid in the presence of dicy-clohexylcarbodiimide (Scheme 60) or the carboxylic acid may be activated by preliminary reaction (mixed anhydride formation) with an appropriate reagent, e.g. Bu COCl , ClCOOEt or ClCOOCHMeEt , or by the use of A-hydroxysuccinimide The... 

Thionyl chloride acetic anhydride Protection of a-aminocarboxylic acid groups as 5-oxazolidones... 

Aminocarboxylic acids from dicarboxylic acid anhydrides... 

Stereospecificity of the Lossen rearrangement Aminocarboxylic acids from dicarboxylic acid anhydrides via N-hydroxydicarboxylic acid imides and N-sulfonyloxydicarboxylic acid imides... 

The phosgenation of isatoic anhydride and aminocarboxylic and amino-sulfonic acids, to afford isocyanatoarylcarbonyl chlorides and isocyanato-arlsylfonyl chlorides, is also catalyzed by iminium chlorides. 

Sodium iminodisuccinate belongs to the aminocarboxylate class of chelating agents. Nearly all anoinocarboxylates in use today are acetic acid derivatives produced from amines, formaldehyde, sodium hydroxide, and hydrogen cyanide. The industrial use of thousands of tons of hydrogen cyanide is an extreme toxicity hazard. In contrast, sodium iminodisuccinate is produced from maleic anhydride (a raw material also produced by Bayer), water, sodium hydroxide, and ammonia. The only solvent used in the production process is water, and the only side product formed—ammonia dissolved in water—is recycled back into sodium iminodisuccinate production or used in other Bayer processes. 

---