1-Aminobenzo triazole

Preliminary studies using the IPPSF have shown that compounds such as the cancer chemotherapeutic agents cisplatin and carboplatin and the antibiotics tetracycline and doxycycline readily distribute into the skin following intravascular administration. Also, compounds such as parathion, 1-aminobenzo-triazole (ABT), and 25-hydroxyvitamin D are bioactivated in the skin following intravascular administration in the IPPSF. This demonstrates a role for the IPPSF as an ideal experimental model for studying the disposition of xenobiotics that are... 

Campbell, C.D. and C.W. Rees (1969). Reactive intermediates. Part 111. Oxidation of 1-aminobenzo-triazole with oxidants other than lead tetra-acetate. 

Sodium nitrite/stannous chloride 1-Aminobenzo triazoles from o-aminoazo compounds... 

Lead tetraacetate Ring closure via benzynes Benzynes from 1-aminobenzo triazoles... 

DeLeve and coworkers (DeLeve et al. 1997) examined the possibility that sinusoidal hepatic endothelial cells may metabolize acetaminophen in vitro and that this may be important in toxicity. Previous data indicated that hepatic endothelial cells contain CYP enzymes (Oesch and Steinberg 1987 Steinberg et al. 1990), and that activation of acetaminophen by CYP enzymes in endothelial cells may produce toxicity. Endothelial cells were isolated from two strains of mice. Acetaminophen was not toxic to cultured endothelial cells from Swiss Webster mice but was toxic to cultured endothelial cells from C3H-HEN mice. Glutathione was depleted in the sensitive endothelial cells before the development of toxicity whereas glutathione was not depleted in endothelial cells from the Swiss Webster mice. Addition of glutathione to the incubation or the CYP inhibitor aminobenzo-triazole inhibited development of toxicity in the C3H-HEN cells. However, the two strains of mice appeared to be equally sensitive to the centrilobular hepatic necrosis produced by acetaminophen in vivo. 

CYP-selective marker assays. W-(a-Methylbenzyl-)-l-aminobenzo triazole. 

A number of chemicals have been developed which act as antagonists to various thiocarbamate herbicides. One such compound, 5-aminobenzo-triazole (ABT), has been reported to neutralize the effect of diallate in plants. Preliminary studies were carried out to determine if ABT caused any effects on fatty acid labeling in test systems. ABT produced some inhibition of total fatty acid labeling in leaf blades from several different... 

Aminobenzo)-5, 6 4,5-(l-hydroxy)-vic-triazole 6-Amina-benzazimidole or 2 -Amino-... 

Oxidation of 1,2-diaminobenzimidazole, leading to the formation in high yield of 3-aminobenzo-l,2,4-triazine 838, is thought to proceed through recyclization of an intermediate nitrene 836 (possibly via diazene intermediate 837) as evidenced by the formation of amine 838, with a high efficiency on the thermolysis of l-amino-2-azidobenzimidazole 835. The reaction works well also for other A -amino—azidoimidazoles and 4-amino-3-azido-l,2,4-triazoles. 

Amine>benzazimidele or 2 Amino-1-hydroxy> IH-benso-triazole. See (2 Aminobenzo)-5, 4.5 (l-hydrozy)-vic-tria2ole... 

Arynes are novel reaction intermediates that react with dienes or 1,3-dipoles to give the corresponding cycloadducts. Recently, many researchers have reported the reaction of benzyne prepared from 2-(trimethylsilyl)phenyl triflate or benzenedia-zonium carboxylate with imines, aminobenzoate, 2-aminobenzophenones, azides, and diazo compounds, which provides various N-containing cycloadducts, such as acridines, acridones, triazoles, and indazoles. Formally, the reaction proceeds in a [2-1-2], [3-1-2], or [4-1-2] manner. Benzyne is an extremely reactive species because of the presence of a strained triple bond and undergoes polar and pericycHc reactions. The lifetime of benzyne in the gas phase has been estimated to around 20 ns (2 X 10" s) by mass spectroscopic techniques. Some spectroscopic properties of benzyne have been determined by Orville Chapman using matrix isolation techniques (Scheme 7.20). 

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