Aminoalkyl groups

The pretreated nylon then undergoes covalent fixation of dyes containing aminoalkyl groups. Interestingly, nylon treated with XLC showed markedly lower substantivity and reactivity with conventional dyes. If the pretreated nylon was reacted with ammonia, however, creating amino functionality at the reactive sites, normal reaction with a conventional reactive dye was restored [405]. 

An aminoalkyl group or a l,5-dihydroxy-4-pyridone group is the preferred substituent in the oxime for strong synergy with various cephalosporin antibiotics, particularly ceftazidime. 

The 4-phenyl and 4-phenyl-2-oxo analogues of (6, n = 3 R1 = R2 = Me) have been reported to exhibit sedative properties [13]. Several carboxamides (7) with a 4-phenyl group have been claimed to be useful as tranquillizers [ 14]. A variety of central effects of the 1-substituted 5-phenyl derivatives (8) has been studied [10]. The 2-(substituted aminomethyl)tetrahydro-l-benzazepine and octahydropyrazino[ l,2-c]-l-benzazepine derivatives have no pharmacological activity on the CNS [15]. 1-Substituted tetrahydro-l-benzazepines having an aminoalkyl group at position 3 are claimed to potentiate the activity of 5-hydroxytryptophan [16]. 

The analogous 4- (19, X = H2) and 5-phenyltetrahydro-l-benzazepines are less active than the 3-phenyl isomers [30]. The corresponding 4-phenyl-benzazepin-2-one (19, X = O) shows moderate antiarrhythmic activity [30] and is claimed to be useful for the treatment of neurogenic or carcinogenic auricular and ventricular fibrillation and as an antihistaminic or local anaesthetic agent [37]. Introduction of an aminoalkyl group, such as 2-piperidinyl-... 

In the case of the naphthalimide fluorescent brightening agents (98) the most important commercial derivatives are the 4-alkoxy and 4-acylamino (e.g. R is methoxy). Substituent R is usually an alkyl group or an aminoalkyl group capable of quaternization. Thus the most interesting of the series is 4-methoxy-Af-methylnaphthalimide, which is an excellent product suitable for application to a variety of synthetic fibres. 

Unusual selectivities have sometimes been observed in the displacement reactions leading to zwitterions equation 17 shows a case of inverse selectivity , in which the aminoalkyl group is displaced, rather than the phenyl, leading to an anionic spirosilicate28. 

Cyclization of chloro derivatives (a). These undergo selective migration of the w-aminoalkyl group to give a pyrrolidine or piperidine (3) on alcoholysis. 

It may be mentioned that some ion-exchange resins having a poly(4-vinylpyridine) matrix partly quaternized with oa-aminoalkyl groups have been prepared and studied with interesting results, as far as their thermal regenerability is concerned 87). This is apparently a recent development of a wide research project on thermally regenerable ion-exchange resins 88>. 

In a study of the stability of phenothiazine drugs carrying dialkyl-aminoalkyl groups in position 10, fission of the side chain was investigated. The number of carbon atoms between the heterocyclic nitrogen and the dialkylamino group was shown to determine the fate of the side chain. 

DOW CORNING Softener SSF is a medium-viscosity polydiorganosiloxane manufactured to yield a substantially linear poly-dimethylsiloxane with reactive aminoalkyl sites. It contains aminoalkyl groups affixed to a predominantly polydimethylsil-oxane structure. 

DOW CORNING Softener SSW is a nonionic emulsion that contains 35 percent of an amine functional silicone fluid. It contains a silicone polymer in which aminoalkyl groups are affixed to a predominantly polydiraethylsiloxane structure. Small amounts of nonionic materials are present to impart stability to the emulsion. Commercially produced emulsions such as DOW CORNING Softener SSW typically contain trace quantities of process impurities. 

A.A.Chuiko, G.E.Pavlik, G.B.Budkevich and I.E.Neimark, A Method of Preparation of Silica Gels Containing Aminoalkyl Group, USSR Patent No. 182 719 (1966). 

The incorporation of a 4 -a-C-aminoalkyl group into thymidine (41) gave a set of building blocks, which were incorporated into DNA. ODNs containing these modifications showed higher thermal stability towards DNA and RNA targets than unmodified DNA. The modified ODNs were also shown to be... 

Ring-opening and reclosure processes using furans include several significant methods for the constraction of pyridines. 2,5-Dihydro-2,5-dimethoxy-furans (see 18.1.1.4) carrying as a C-2 side-chain an aminoalkyl group, give rise to 3-hydroxy-pyridines. ... 

N > activity by N-atkyl, haloalkyl, alkynyl and small cycle or aminoalkyl groups ... 

Affinity Separation - Treatment of dCTP with carbonylbis(imidazole) followed by N-trifluoroacetyl-6-aminohexyl phosphate affords (191), which was deacetylated and coupled via its aminoalkyl group to CNBr-Sepharose, affording a P4 (dC) affinity column (192).326 This column gave a one-step, 19,000-fold purification to homogeneity of deoxycytidine kinase from a crude ammonium sulphate fraction of Lactobacillus acidophilus R-26 extract, with 60 % recovery, a striking instance of the power of affinity chromatography. Elution from the column was performed with dCTP, which is a powerful end-product inhibitor for the enzyme and serves to stabilize it. 

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