2-Amino-n-octane

Amino-n-octane. Convert methyl n-hexyl ketone (Section 111,71) into the ketoxime, b.p. 106-108°/12 mm., as detailed for n-Heplaldoxime (Section 111,76). Reflux a solution of 50 g. of the oxime in 200 ml. of... 

Amino-5-methylthiazole. 841 2-Amino-n-octane, 413, 419 p-Aminophenol, 628, 630 p-Aminophenylacetic acid, 764 2-Aminopyridine, 993, 1007 2-Aminothiazole, 840 Ammonia, 184 see also Liquid ammonia... 

Cr(CO)g] reacts with the 2-acylpyrroles RCOC HgNH (R = H, Me, or Ph) in refluxing n-octane to give tris(2-acylpyrrolato)chromium(iii) complexes (63) as dark-yellow or red crystalline solids. 2-Aminophenol-4-arsonic acid and K2Cr2 07 react to form the analogous dark-red complex (64). " The complexes of 8-amino-7-hydroxy-4-methylcoumarin (HL) (65), [Cr(L)Cl2(H20)2] and (HL)[Cr(L)2(0H)(H20)], have been characterized and the existence of... 

An efficient asymmetric synthesis of the 3-substituted /3-sultams 163 has been reported. The key step of the synthesis is the Lewis acid-catalyzed aza-Michael addition of the enantiopure hydrazines (A)-l-amino-2-methoxy-methylpyrrolidine (SAMP) or CR,l ,l )-2-amino-3-methoxymethyl-2-azabicyclo[3.3.0]octane (RAMBO) to the alke-nylsulfonyl sulfonates 176. /3-Hydrazino sulfonates were obtained in good yield and excellent enantioselectivity. Cleavage of the sulfonates followed by chlorination resulted in the corresponding sulfonyl chlorides 177. The (A)-3-substituted /3-sultams 163 have been obtained in moderate to good yields and high enantioselectivity over two steps, an acidic N-deprotection followed by in situ cyclization promoted by triethylamine (Scheme 55) <2002TL5109, 2003S1856>. 

Benzothiophen 2-Amino-3-cyan-5,7-dimethyl- E6a, 223 (Cyclohe-xanon + NC—CH2 —CN/S8) Cyclooctalblthiophen 2-Amino-6-tert.-butyl-3-cyan-4,5,6,7,8,9-hexahydro- E6a, 223 (Oxo-cyclo-octan + NC —CH2 —CN/S8) Sulfimid N-(4-Cyan-phenyl)-S-methyl-S-propyl- Ell, 896 (R2S + R-NH2/NCS)... 

Stabilizers UVA 2-hydroxy-4-methoxybenzophenone 2,4-dihydroxy-benzophenone 2-benzotriazol-2-yl-4,6-di-tert-butylphenol 2-(2H-benzotriazole-2-yl)-4,6-di-tert-pentylphenol N-(2-ethoxyphenyl)-N -(4-isododecylphenyl)oxamide HAS decane-dioic acid, bis(2,2,6,6-tetramethyl-1-(octyloxy)-4-piperidinyl) ester, reaction products with 1,1-dimethylethylhydroperoxide and octane 2,4-bis[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetra-methylpiperidin-4-yl)amino]-6-(2-hydroxyethylamine)-1,3,5-trlazlne bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate and methyl 1,2,2,6,6-pentamethyl-4-piperidyl sebacate 2-dodecyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide polymer of 2,2,4,4-tetramethyl-7-oxa-3,20-diaza-dispiro [5.1.11,2]-hene-lcosan-21-on and epichlorohydrin Screener Ti02 Phosphite phosphoric acid, (2,4-di-butyl-6-methylphenyl)ethylester ... 

Constitution. When coniine is distilled with zinc dust or heated with silver acetate/ a new base, coiiyrine, CgH N, differing from coniine by six atoms of hydrogen, is formed. This on oxidation yields pyridine-2-carboxylic acid and, since it is not identical with 2-isopropylpyridine, must be 2-propylpyridine (I). When coniine is heated with hydriodic acid at 300° it yields w-octane (II). These and other observations due mainly to A. W. Hofmann, made it clear by 1885 that coniine was probably a-propylpiperidine (III), and this has been amply confirmed by other reactions of the alkaloid and by syntheses. Thus, Wolffenstein showed that on oxidation with hydrogen peroxide, coniine is converted into amino-w-propylvaleraldehyde (IV) ... 

To a suspension containing 4.86 parts of 4-methylbenzenesulfonyl urethane (MP 80° to 82°C) and 36 parts of anhydrous toluene there are rapidly added 2.5 parts of N-amino-3-azabicyclo(3.3.0)octane (BP/18 mm = 86°C). The reaction mixture is heated under reflux for 1 hour. The resulting ciear solution crystallizes on cooling. The crystals are filtered, washed with 2 parts of toluene, then recrystallized from anhydrous ethanol. There are obtained 3.8 parts of the desired product, MP 180° to 182°C. 

El Tayar, N. Tsai, R.-S. Carrupt, P.-A. Testa, B., Octan-l-ol-water partition coefficinets of zwitterionic a-amino acids. Determination by centrifugal partition chromatography and factorization into steric/hydrophobic and polar components, J. Chem. Soc. Perkin Trans. 2, 79-84 (1992). 

PREPARATION OF 1-[N-BENZYLOXYCARBONYL-(1S)-1-AMINO-2-OXOETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE [Carbamic acid, [1 -(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1 -yl)-2-oxoethyl]-, phenylmethyl ester, (S)-]... 

D. 1 -[N-Benzyloxycarbonyl-(IS)-1 -amino-2-oxoethyl]-4-methyl-2,6,7-trioxabi-cyclo[2.2.2]octane, [Cbz-L-Ser(ald) OBO ester, (4)7 Cbz-Ser OBO ester 3 (9.10 g, 28.0 mmol) (Note 21) is dissolved in dry CH2CI2 (80 mL) (Note 14) under Ar and cooled to -78°C in a 100-mL, round-bottomed flask labeled flask 1. Oxalyl chloride (3.9 mL, 45 mmol, 1.61 equiv) (Note 22) is added to dry CH2CI2 (120 mL) (Note 14) in a separate 250-mL, round-bottomed flask (flask 2) under Ar, and cooled to -78°C. Dry dimethyl sulfoxide (DMSO, 7.0 mL, 90 mmol, 3.21 equiv) (Note 23) is added to the oxalyl chloride solution (flask 2) and the mixture is stirred under Ar (magnetic stir bar) at -78°C for 15 min. The alcohol solution 3 (in flask 1) is transferred slowly by cannula to flask 2 over a period of 45 min and then rinsed with dry CH2CI2 (50 mL) (Note 14). The resulting cloudy white... 

PREPARATION OF 1-[N-BENZYLOXYCARBONYL-(1S)-1-AMINO-2-OXOETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE... 

The checkers also prepared racemic 1-[N-benzyloxycarbonyl-(1 )-1-amino-2-hydroxyethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane using the identical procedure (50% over 2 steps from racemic Cbz-serine purchased from Aldrich Chemical Company, Inc.). The enantiomeric ratio of the crystalline (S)-3 enantiomer (Note 20) was > 99.5 0.5 as determined by comparison with racemic 3 by courtesy of Mr. Eric Hortense (GlaxoSmithKline, Stevenage). Chiral HPLC (25 cm Chlracel OD-H, Column No ODHOCE-IF029, mobile phase ethanol/heptane 1 4 v/v, UV detector at 215 nm, flow rate... 

Amino-octan3 Zu einem Gemisch von 0,281 g (2,28 mol) N-Benzyl-hydroxylamin, 0,2675 g (1,04 mmol) Tetraethylammonium-jodid und 2 ml Phosphorsaure-tris-[dimethylamid] gibt man unter Inertgas ein Ge-misch von 0,402 g (2,08 mmol) 1-Brom-octan, 0,253 g (2,5 mmol) Triethylamin und 2 ml Phosphorsaure-... 

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