2-Amino-6-methyldipyrido imidazole

Amino-2-methylanthraquinone 2-Amino-3-methylimidazo[4,5-/]quinoline (see IQ) 2-Amino-6-methyldipyrido[l,2-a 3, 2 -fil]imidazole (see Glu-P-1) 2-Amino-l-methyl-6-phenylimidazo[4,5-6]pyridine (see PhIP)... 

Tryptophan pyrolysates have also been found to induce sister chromatid exchanges in cultured mammalian cell lines. Tohda et al. (35) tested Trp-P-1, Trp-P-2, 2-Amino-6-methyldipyrido[l,2-oi 3, 2 -dj imidazole(Glu-P-1), and AaC in a permanent cell line of human lymphoblastoid cells. All four compounds were active at a concentration of 10 M, but inclusion of S9 mix was necessary. Similar results are reported by Sasaki, a. (34) in 2 human and Chinese hamster cell lines. 

Trp-P-1 3-amino-1,4-dimethyl-5//-pyrido[4,3-fe]indole Trp-P-2 3-amino-l-methyl-5//-pyrido[4,3-fe]indole Glu-P-1 2-amino-6-methyldipyrido[l,2-a 3, 2 -ct]imidazole Glu-P-2 2-aminodipyrido[ 1,2-a 3, 2 -rf]imidazole Phe-P-1 2-amino-5-phenylpyridine... 

FIGURE 9.3 Total gas chromatogram obtained from standard heterocyclic amines (containing 5 ng of each amine). GC conditions-peaks 1. 2-amino-9H-pyrido[2,3-b]indole (AaC) + 2-aminodipyrido [l,2-a 3 2Cd]imidazole (Glu-p-2) 2. 2-amino-6-methyldipyrido[l,2-a 3 2Cd]imidazole (Glu-P-1) 3. 3-amino-l,4-dimethyl-5H-pyrido[3,4-b]indole (Trp-P-1) 4. 3-amino-l-methyl-5H-pyrido[3,4-b]indole (Trp-P-2) ... 

Yamamoto et al. (4365a) reported the isolation and identification of 2-amino-6-methyldipyrido[l,2-a 3 ,2 -from glutamic acid pyrolysates. 

AaC = 2-amino-9/7-pyrido[2,3-h]indole MeAaC = 2-araino-3-methyl-9//-pyrido[2,3-h]indole Glu-P-1 = 2-amino-6-methyldipyrido[l,2-a 3 ,2 -rf imidazole Glu-P-2 = 2-aminodipyrido[l,2-a 3 ,2 -rf imidazole PhlP = 2-amino-l-methyl-6-phenyl-l//-imidazo[4,5-h]pyridine IQ = 2-amino-3-methyl-3//-imidazo[4,5-/ quinoline MelQ = 2-amino-3,4-dimethyl-3//-imidazo[4,5-/ quinohne Trp-P-1 = 3-amino-l,4-dimethyl-5//-pyrido[4,3-Z<]indole Trp-P-2 = 3-amino-l-methyl-5i/-pyrido[4,3-h]indole > See Table 3 in (1740). 

Amino-6- methyldipyrido [l,2-a 3, 2 -ii imidazole Glu-P-1 1iHioN4 198 6.0 Less-polar 0... 

FIGURE 49.6 (A) Recorded elution profile of analyte and respective blank zones (marked with an asterisk) and (B) sum spectrum of elution peak 3 showing Glu-P-1 (2-amino-6-methyldipyrido[l,2-a 3, 2 -d]imidazole, m/z 199 [M-tH], m/z 221 [M-fNa] ). 

An excellent separation of 14 heterocyclic aromatic amines (e.g., aminoimida-zoazaarenes such as 2-amino-3,8-dimethylimidazo[4,5/]quinoxaline glutamic acid pyrolysates such as 2-amino-6-methyldipyrido[l,2-a 3 2 -d]imidazole carbolines such as 3-amino-l,4-dimethyl-5f/-pyrido[4,3/]indole) extracted from fried or broiled meats was developed on a Cig column (A = 263 nm). A complex 55-min 5/95/0 15/85/0 -> 15/0/85 -> 55/0/45 acetonitrile/water (lOmM TEA... 

Cl1H7NO, 5-Keto-1,5-dihydrobenz[cd]indole, 38B, 299 C11H8N4O2, 10-Methylisoalloxazine, 39B, 208 Cl1H9N3, 2-Methyl-2H-naphtho[1,8-de]triazine, 46B, 267 C11H10N4, 2-Amino-6-methyldipyrido[1,2-a 3, 2 -d]imidazole, 45B, 293 CiiHiiBrN 2 H2O, 2-Amino-6-methyldipyrido[1,2-a 3 ,2 -d]imidazole hydrobromide dihydrate, 45B, 293... 

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