4- Amino-l-dimethylamino

In einem Autoklaven erhitzt man 60 g (0,3 mol) 2-Brom-1,1-diethoxy-ethan und 88 g (1 mol) 2-Amino-1-dimethylamino-ethan 7h auf 120". Nach dem Abkuhlen wird mit 100 m/ 50%iger waBr. Natronlauge gewaschen und die organ. Phase uber Natriumcarbonat getrocknet, Durch fraktionierte Destination erhalt man 50 g nicht umgesetztes 2-Amino-l-dimethylamino-ethan und 42 g Produkt Ausbeute 42 g (70%) Sdp. 105712 Torr (1,6 kPa). 

Anwendung dieser Reaktionen auf Allyl-dimethyl-amin ergibt l-Dimethylamino-2-phthal-imido-propan bzw. l-Dimethylamino-2-(4-methyl-benzolsulfonylamino)-propan, deren in ublicher Weise zu erhaltende Spaltungsprodukte 2-Amino-l-dimethylamino-propan bzw. l-Dimethylamino-2-methylamino-propan sind. 

Amino-l-(dimethylamino-methyl)- 475 2-Amino-l-diphenylamino- 685 2-Amino-l-methoxy- 536 4-Amino-l-methoxy- 477... 

Treatment of 2-amino-5-nitrothiobenzamide with iV,iV-dimethylformamide dimethyl acetal gives 2-amino-iV-((dimethylamino)methylene)-5-nitrobenzothioamide 191 in excellent yield <2004TL5913>. Cycloaddition reaction of 191 with DMAD results in formation of dimethyl 2-(2-amino-5-nitrophenyl)-4-(dimethylamino)-4//-l,3-thiazine-5,6-dicarboxylate 192 in low yield when R = H. This is caused by cycloreversion of thiazine 192 to give dimethyl 2-((dimethylamino)methylene)-3-thioxosuccinate 193 and 2-amino-5-nitrobenzonitrile 194 (Scheme 19). When W((dimethylamino)methylene)-2-(alkylamino)-5-nitrothiobenzamides 191 (R = Me, Bn) are reacted with DMAD, the expected 4//-l,3-thiazine-5,6-dicarboxylates 195 are produced as stable compounds. 

Die Umsetzung von 5-Acetyl-2-amino-l,3-oxazol mit sekundaren Aminen fiihrt zu Gemischen aus 4(5)-Acetyl-2-dimethylamino-imidazolen (32-62%) und 2-Dimethylamino-5-hydroxy-4-methyl-pyrimidinen (15-44%)387 ... 

Aluminum Identification Test, 753 Aluminum Magnesium Silicate, 41 Aluminum Potassium Sulfate, 21 Aluminum Sodium Sulfate, 21 Aluminum Sulfate, 22 Ambrette Seed Liquid, 23 Ambrette Seed Oil, 23, 596 Aminoacetic Acid, 186 A-[4-[[(2-Amino-l,4-dihydro-4-oxo-6-pteridinyl)methyl] amino] benzoyl] -l-glutamic Acid, 157 3 - Amino-7-dimethylamino-2-methylphenazine Chloride, 861 L-2-Aminoglutaramic Acid, 175 L-2-Amino-5-guanidinovaleric Acid, 32, (S3)5... 

As a rule, oxadiazoles and thiadiazoles are not nitrated. Reports on the production of 2-nitro-5-amino-l,3,4-thiadiazole during the nitration of 2-amino-l,3,4-thiadiaz-ole [274] proved erroneous [275], The compound obtained in this case was 2-nit-ramino-l,3,4-thiadiazole [275], There is only a single paper on the nitration of derivatives of 1,3,4-oxa- and 1,3,4-thiadiazoles [276], 2-Dimethylamino-l,3,4-oxa-and 2-dimethylamino-l,3,4-thiadiazoles react with the nitrating mixture with the formation of 2-dimethylamino-5-nitro derivatives. Aryl-substituted oxadiazoles and thiadiazoles are nitrated in the phenyl ring [277, 278],... 

Methoxy-2-phenylethan-2-one 1 -Phenoxy-2-phenylethan-2-one 1 -Amino-2-phenylethan-2-one l-Pyrrolidinyl-2-phenylethan-2-one l-Dimethylamino-2-phenylethan-2-one l-Diphenylamino-2-phenylethan-2-one l-Phenylmethylsulfanyl-2-phenylethan-2-one l-Phenylsulfanyl-2-phenylethan-2-one l-Phenylselenyl-2-phenylethan-2-one 1 -Cyano-2-phenylethan-2-one 1 -Nitro-2-phenylethan-2-one l-Phenylsulfonyl-2-phenylethan-2-one... 

Abweichend von dem vorstehenden Reaktionsverlauf ist aus 2-Chlor-N,N-dimethyl-N -(4-me-thyl-benzosulfonyl)-acetamidin und Thioharnstoff nicht 2-Amino-4-(4-methyl-benzolsulfonyl-amino)-l, 3-thiazolium-chlorid, sondern 2-Amino-4-dimethylamino-1,3-thiazolium-chlorid erhal-ten wordcn439. 

Amino-l,3-oxazin-6-ones can be isolated as crystalline compounds and, for example, the structures of 2-amino-5-cyano-4-methylthio-l,3-oxazin-6-one (12) <85HCA1155>, 5-ethoxycarbonyl-2-(A,A-dimethylamino)-4-phenyl-l,3-oxazin-6-one (13), and 4-ethoxycarbonyl-2-(A7,A-dimethyl-... 

Amino-l,2-dihydroacronycine (40 ) could be easily converted into variously substituted amines and amides. Treatment of 40 with formaldehyde and sodium borohydride afforded 2-dimethylamino-l,2-dihydroacronycine (42). Both aliphatic and aromatic amides were obtained from 4 upon treatment with acid anhydrides in pyridine. This latter reaction is exemplified by the preparation of 2-acetylamino-l,2-dihydroacronycine (43J and 2-benzoylamino-l,2-dihydroacronycine (44) using acetic anhydride and benzoic anhydride, respectively (53). 

The deprotonation of 2-amino-l,2,3-triazinium salts 97a,c,d to 1,2,3-triazinium 2-imines 18d,f,g has been treated in Section 9.01.5.2 (see Equation 19), and for the conversion of 18d,f,g with electron-deficient alkynes into Michael adducts and cycloadducts, see Scheme 11 (Section 9.01.5.7). 4,6-Diphenyl-l,2,3-triazine 2-imine 18f has been methylated with Mel at the imino N-atom to give 2-dimethylamino-4,6-diphenyl-l,2,3-triazinium iodide, and... 

Amino 7 dimethylamino>l>methyl 4 i80 propyl-phenazin S5 II342. 

Synthesis was accomplished of the s-triazine derivatives from uronic and polyuronic acids.5(R)-(2-Amino-4-di-methylamino-l,3,5-triazin-6-yl)-L-arabinopyranose and its methyl glucoside were prepared from gaiact-uronic acid. 5(R)-(2-amino-4-dimethylamino-l,3,5-triazin-6-yl)-p-d-xylo-pyranose was prepared from glucuronolactone. Methyl 5(R)-(2-Amino-4-di-methyl-amino-1,3,5-triazin-6-yl)-a-D-lyxopyranoside was prepared from mannuronolactone by ring closure with N,N-disubstituted biguanide. s-Triazine derivatives of polyuronic acids, such as pectin and alginic acid, were prepared similarly. 

Comparison of the UV speetra of 5-amino-2-(2-furyl)-l,2,4-triazolo[l,5-cjquinazolines (196) and its 5-methylamino derivative (197) in neutral, aeidie, and basie media with the speetra of the two tautomerieally looked derivatives—2-(2-furyl)-5-dimethylamino-l,2,4-triazolo[l,5-c]quinazolines (198) (amino-loeked tautomers) and the imino-loeked tautomers 2-(2-furyl)-5-imino-6-methyl-l,2,4-triazolo[l,5-c]quinazolines (199)—indieated that eompounds 196 and 197 are best represented as a mixture of their amino and imino tautomers (88JMC1014) (Seheme 75). 

Reaction of 2-amino-4/f-pyrido[l,2-n]pyrimidin-4-ones 143 with HNMei -HCl and paraformaldehyde in Dowtherm A afforded a mixture of 3-(A,A-dimethylamino)methyl derivatives 144 and bis-compounds 145 (93FES1225). Mannich reaction of 9-hydroxy-2-methyl-4//-pyri-dor],2-nlpyrimidin-4-one (146) yielded 8-aminomethyl derivatives 147 (94KFZ(10)23). 

Der. 134f.( 258-261, 366ff., 479 182, 488, 523 2-AthyI-1-[l-dimethylamino-propyI-(2)]- 259 2-Athyl-l-phenyl- 258 2-AIkyl-1,2-diphenyl- 259 2-Alkyliden-l-acyl- 261 (Amino-aryl)- 489 2-(3-Amino-propyl)-l-benzoyI-... 

Recent examples of this synthesis are of two types. The first involves condensation of the activated phenol, 2-amino-4,6-dinitrophenol (346a) with 2-dimethyl-amino-3,3-dimethyl-3//-azirine (346b) (in MeCN, 0°C- 20°C, A, 24 h) to afford a separable mixture of four products, one of which was 2-dimethylamino-3,3-dimethyl-5,7-dinitro-3,4-dihydroquinoxaline (346c) ( 20% yield) and another its hydrolysis product, 3,3-dimethyl-5,7-dinitro-3,4-dihydro-2(l//)-quinoxalinone (346d) ( 8%) the mechanism of such condensations has been discussed. ... 

A stronger donor, the butadiene with the amino groups in place of the methoxy group in the 1,4-positions, was calculated to react with TCNE via a zwitterion (pseudoexcitation band in Scheme 7) [34], The loss of the stereochemical integrity was observed inthe[4+2]cycloadditionreactionsbetweensomestrongdonors,l,4-bis(dimethylamino) butadienes, and acceptors, fumaric and maleic dinitriles [36],... 

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