Amino group, compounds containing

P-Amino carbonyl compounds containing an a-atkyUdene group are densely functionalized materials, which are widely applied in the synthesis of medicinal reagents and natural products [265]. These products are usually prepared through the classic aza-Morita-Baylis-Hillman reaction [176, 177] of activated imines and electron-deficient alkenes catalyzed by tertiary amines or phosphines. Chen and co-workers, in 2008, identified bis-thiourea 106 as a suitable catalyst for the... 

Amino acids - Compounds containing both a carboxylic acid group (-COOH) and an amino group (-NH ). The most important are the a-amino acids, in which the -NH group in attached to the C atom adjacent to the -COOH group. In the [5-amino acids, there is an intervening carbon atom. [4]... 

The reaction between 3,5 dinitrobenzoyl chloride and compounds containing the OH, NHj, or NH groups is very rapid, and therefore is particularly suitable for identification purposes cf. pp. 335, 338, 381). It is usual to have sodium hydroxide present during the reaction with phenols and amino-acids, but this is not necessary with alcohols if they are dry. 

Compounds containing two primary amino groups attached to a benzene ring can be prepared by the reduction of dinitro compounds and of nitroanilines, usually with tin or stannous chloride and hydrochloric acid or with iron and very dilute hydrochloric acid. / ara-diamines may also be obtained by the reduction of aromatic amino-azo compounds (e.g., p-aminodimethylanihne from methyl orange, see Section IV,78). p-Phenylenediamine may also be prepared from p-nitroacetanilide reduction with iron and acid yields p-amino-acetaniUde,.which may be hydrolysed to the diamine. 

Acetates may also be prepared by adding acetic anhydride to somewhat dilute solutions of compounds containing hydroxyl (or amino) groups in aqueous caustic alkahs. The amount of alkali used should suffice to leave the hquid shghtly basic at the end of the operation, so much ice should be added that a little remains unmelted, and the acetic anhydride should be added quickly. 

Amino resins are thermosetting polymers made by combining an aldehyde with a compound containing an amino (—NH2) group. Urea—formaldehyde (U/F) accounts for over 80% of amino resins melamine—formaldehyde accounts for most of the rest. Other aldehydes and other amino compounds are used to a very minor extent. The first commercially important amino resin appeared about 1930, or some 20 years after the introduction of phenol—formaldehyde resins and plastics (see Phenolic resins). 

The versatility of lithium aluminum hydride permits synthesis of alkyl, alkenyl, and arylsilanes. Silanes containing functional groups, such as chloro, amino, and alkoxyl in the organic substituents, can also be prepared. Mixed compounds containing both SiCl and SiH cannot be prepared from organopolyhalosilanes using lithium aluminum hydride. Reduction is invariably complete. 

This intermediate attacks compounds containing a variety of functional groups, such as primary, secondary, and tertiary amino nitrogen atoms, carboxyl groups, and sulfhydryl groups (10). 

Primary amino groups attached to azole rings react normally with nitrous acid to give diazonium compounds via primary nitroso compounds. However, the azole series shows two special characteristics the primary nitroso compounds can be stable enough to be isolated, and diazo anhydrides are formed easily from azoles containing ring NH groups. 

Certain nucleophilic sp ies add to carbonyl groups to give tetrahedral intermediates that are unstable and break down to form a new double bond. An important group of such reactions are those with compounds containing primary amino groups. Scheme 8.2 lists some of the more familiar classes of such reactions. In general, these reactions are reversible, and mechanistic information can be obtained by study of either the forward or the reverse process. 

Phosphorus-nitrogen compounds containing alkylated amino groups can be cleaved by fluormatmg agents Phenyldifluorophosphine is formed from the reaction of A,MA, lV -tetramethylphenylphosphonous amide and benzoyl fluoride [79] (equation 17). 

Polyamine (Section 22.4) A compound that contains many amino groups. The term is usually applied to a group of naturally occurring substances, including spermine, spermidine, and putrescine, that are believed to be involved in cell differentiation and proliferation. 

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