5- Benoxaprofen chloride

Indirect chiral separation was performed derivatizing metoprolol, oxprenolol, and propranolol with 5-(- -)-benoxaprofen chloride, pindolol with 2,3,4,6-tetra-0-acetyl-/S-D-glucopyranosyl-isothiocyanate and propranolol, alprenolol, pindolol, oxprenolol, and bunitrolol with f -(—)-l-(l-naphthyl)ethyl isocyanate. The formed derivatives were further resolved to antipodes using achiral stationary phases. 

Enantiomers of metoprolol were determined in urine after the extraction with toluene at pH 9.9 and derivatization with 5 -(+)-benoxaprofen chloride [18]. 

Procedure B [99] Dissolve the free amine in a solution of R — )-benoxaprofen chloride (10% w/v in dichloro-methane, 0.5 ml) and keep the solution at room temperature for 30 min. Analyse the reaction mixture directly... 

R.( ). I.(I -Naphthyl)ethyl isocyanate (Ega Chemie, Steinheim, Germany) (S)-(+)-Benoxaprofen chloride (benoxaprofen, Eli Lilly, Bad Homburg, Germany)... 

The following chiral reagents were employed for diastereomer formation before sample application and chromatography on silica gel or silica gel G TLC plates (L)-leucine Af-carboxyanhydride for D,L-dopa-carboxyl- " C separated with ethyl acetate/formic acid/water (60 5 35) mobile phase and detected by ninhydrin [7 f 0.38 (d)/0.56 (l)] [43] Af-trifluoroacetyl-L-prolyl chloride for D,L-amphetamine separated with chloroform/methanol (197 3) and detected by sulfuric acid/formaldehyde (10 1) (Rf 0.49 (d)/0.55 (l)) [44] Af-benzyloxycarbonyl-L-prolyl chloride for D,L-methamphetamine separated with n-hexane/ethyl acetate/acetonitrile/diisopropyl ether (2 2 2 1) and detected by sulfuric acid/formaldehyde (10 1) [/ f 0.57 (l)/0.61 (d)] [44] (l/ ,2/ )-(-)-l-(4-nitrophenyl)-2-amino-1,3-propanediol (levobase) and its enantiomer dextrobase for chiral carboxylic acids separated with chloroform/ethanol/acetic acid (9 1 0.5) and detected under UV (254 nm) light R[ values 0.63 and 0.53 for 5- and / -naproxen, respectively) [45] (5)-(4-)-a-methoxyphenylacetic acid for R,S-ethyl-4-(dimethylamino)-3-hydroxybutanoate (carnitine precursor) with diethyl ether mobile phase [/ f 0.55 R)/0J9 (5)] [46] and (5)-(4-)-benoxaprofen chloride with toluene/acetone (100 10, ammonia atmosphere) mobile phase and fluorescence visualization (Zeiss KM 3 densitometer 313 nm excitation, 365 nm emission) (respective R values of R- and 5-isomers of metoprolol, oxprenolol, and propranolol were 0.24/0.28, 0.32/0.38, and 0.32/0.39) [47]. 

A method for rapid determination of the enantiomers of propranolol after extraction from urine samples at pH 9.9 using toluene was developed. Enantiomers were determined after derivatization with -(-D-benoxaprofen chloride [18]. The established determination conditions are described in Section 14.2.3.3. 

N-p-Chlorobenzohydryl piperazine Hydroxyzine HCI o-Chlorobenzo nitrile Ketamine HCI o-Chlorobenzophenone Chlophedianol 4-Chlorobenzophenone Chlorphenoxamine HCI p-Chlorobenzoyl chloride Benoxaprofen... 

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