Mutagenicity amines

Kami H, T Watanabe, S Takemura, Y Kameda, T Hirayama (2000) isolation and chemical-structural identification of a novel aromatic amine mutagen in an ozonized solution of m-phenylenediamine. Chem Res Toxicol 13 165-169. 

R. Edenharder, 1. von Petersdorff, and R. Rauscher, Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo(4,5-f quinoline (IQ) and other heterocyclic amine mutagens from cooked food. Mutat Res. 287 261 (1993). 

Toropov AA, Toropova AP (2001) Prediction of heteroaromatic amine mutagenicity by means of correlation weighting of atomic orbital graphs of local invariants. J. Mol. Struct. (Theochem) 538 287-293. 

Gramatica, P., Consonni, V. and Pavan, M. (2003) Prediction of aromatic amines mutagenicity from theoretical molecular descriptors. SAR ei QSAR Environ. Res., 14, 237-250. 

A U. S. National Research Council report concludes that natural and synthetic carcinogens are present in human foods at such low levels that they pose little threat.42 It points out that consuming too many calories as fat, protein, carbohydrates, or ethanol is far more likely to cause cancer than consuming the synthetic or natural chemicals in the diet. However, it also mentions several natural substances linked to increased cancer risk heterocyclic amines formed in the overcooking of meat nitrosoamines, aflatoxins, and other mycotoxins.43 Typical of the heterocyclic amine mutagens are compounds 1.9 and 1.10, the first from fried beef and the second from broiled fish 44... 

Moriwaki, H., Harino, H., Hashimoto, H., Arakawa, R., Ohe, T., and Yoshikura, T., Determination of aromatic amine mutagens, PBTA-1 and PBTA-2, in river water by SPE followed by liquid chromatography-tandem mass spectrometry, J. Chromatogr. A, 995, 239-243,... 

A novel method was described for the determination of two kinds of aromatic amine mutagens... 

Moriwaki describes a novel method for the determination of two kinds of aromatic amine mutagens, 2-[2-(acetylamino)-4-[bis(2-methoxyethyl)-amino]-5-amino-7-bromo-... 

McManus, M.E., W.M. Burgess, M.E. Veronese, A. Huggett, L.C. Quattrochi, and R.H. Tukey (1990). Metabolism of 2-acetylaminofluorene and benzo[a]pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 50, 3367-3376. 

V-Heterocyclic Amines Mutagenicity of Beverages, Heated Foods, and Heated Food Components... 

While many of the A-heterocyclic amine mutagens are present in tobacco smoke, the extensive research on this class of compounds was initiated and extended because of their presence in many foodstuffs consumed by many people. Table XXVI-5 summarizes some details of these A-heterocyclic amines in tobacco smoke. 

OTHER COMMENTS used in the laboratory by biochemists in the study of liver en zymes carcinogenesis of aromatic amines mutagenicity of aromatic amines. 

Dashwood, R.H., Yamane, S., and Larsen, R., A study of the forces stabiUzing complexes between chlorophylls and heterocycUc amine mutagens. Environ. Mol Mutagen., 27, 211, 1996. 

Diisopropyl- amine Mutagenicity negative, Ames [107] Mutagenicity questionably positive, Ames, 1 tg per plate [102, 108] DNA repair negative, rat hepatocyte primary culture assay [104] Guinea pig sensitizer, negative [104]... 

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