Mechanism amide reduction

Not a great deal of work has been done on the acid or ester reduction mechanisms. There is no fundamental reason why a carboxylic acid should not be reduced electrolytically just as easily as the ester or amide. However, one... 

Marcus treatment does not exclude a radical pathway in lithium dialkyl-amide reduction of benzophenone. It does, however, seem to be excluded (Newcomb and Burchill 1984a,b) by observations on the reductions of benzophenone by N-lithio-N-butyl-5-methyl-l-hex-4-enamine in THF containing HMPA. Benzophenone is reduced to diphenylmethanol in good yield, and the amine yields a mixture of the acyclic imines no cyclic amines, expected from radical cyclization of a putative aminyl radical, were detected. An alternative scheme (17) shown for the lithium diethylamide reduction, accounts for rapid formation of diphenylmethoxide, and for formation of benzophenone ketyl under these conditions. Its key features are retention of the fast hydride transfer, presumably via the six-centre cyclic array, for the formation of diphenylmethoxide (Kowaski et al., 1978) and the slow deprotonation of lithium benzhydrolate to a dianion which disproportion-ates rapidly with benzophenone yielding the ketyl. The mechanism demands that rates for ketyl formation are twice that for deprotonation of the lithium diphenylmethoxide, and, within experimental uncertainty, this is the case. 

Problem-Solving Strategy Proposing Reaction Mechanisms 1007 Mechanism 21-8 Transesterification 1008 21-7 Hydrolysis of Carboxylic Acid Derivatives 1009 Mechanism 21-9 Saponification of an Ester 1010 Mechanism 21-10 Basic Hydrolysis of an Amide 1012 Mechanism 21-11 Acidic Hydrolysis of an Amide 1012 Mechanism 21-12 Base-Catalyzed Hydrolysis of a Nitrile 1014 21-8 Reduction of Acid Derivatives 1014... 

The mechanism, illustrated in Mechanism 20.5 with RCONH2 as starting material, is somewhat different than the previous reductions of carboxylic acid derivatives. Amide reduction proceeds with formation of an intermediate imine, a compound containii a C-N double bond, which is then further reduced to an amine. 

Scheme 26 Supposed mechanism of amide reduction by BH3 and subsequent hberation of the resulting amino-borane complex [30]...

Acid halides are among the most reactive of carboxylic acid derivatives and can be converted into many other kinds of compounds by nucleophilic acyl substitution mechanisms. The halogen can be replaced by -OH to yield an acid, by —OCOR to yield an anhydride, by -OR to yield an ester, or by -NH2 to yield an amide. In addition, the reduction of an acid halide yields a primary alcohol, and reaction with a Grignard reagent yields a tertiary alcohol. Although the reactions we ll be discussing in this section are illustrated only for acid chlorides, similar processes take place with other acid halides. 

It is of incidental interest that a little work has been done on dicobalt systems. Doyle and Sykes have made a study of the reduction of decammine-//-amidodi-cobalt(Ill), (NH3)5Co NH2-Co(NH3)5 , by V(II). Since the rate is independent of hydrogen-ion concentration the mechanism cannot involve an amide bridge and must be outer-sphere, as it is in the case of the reduction of Co(NH3)6 by V(1I) . Both the binuclear complex and Co(NH3)6 are inert to substitution but the former is capable of functioning as a two-equivalent oxidant. Thus the two likely mechanisms are... 

Amides can also be deacylated by partial reduction. If the reduction proceeds only to the carbinolamine stage, hydrolysis can liberate the deprotected amine. Trichloroac-etamides are readily cleaved by sodium borohydride in alcohols by this mechanism.237 Benzamides, and probably other simple amides, can be removed by careful partial reduction with diisobutylaluminum hydride (see Section 5.3.1.1).238... 

Although polymers in-service are required to be resistant toward hydrolysis and solar degradation, for polymer deformulation purposes hydrolysis is an asset. Highly crystalline materials such as compounded polyamides are difficult to extract. For such materials hydrolysis or other forms of chemolysis render additives accessible for analysis. Polymers, which may profitably be depolymerised into their monomers by hydrolysis include PET, PBT, PC, PU, PES, POM, PA and others. Hydrolysis occurs when moisture causes chain scissions to occur within the molecule. In polyesters, chain scissions take place at the ester linkages (R-CO-O-R ), which causes a reduction in molecular weight as well as in mechanical properties. Polyesters show their susceptibility to hydrolysis with dramatic shifts in molecular weight distribution. Apart from access to the additives fraction, hydrolysis also facilitates molecular characterisation of the polymer. In this context, it is noticed that condensation polymers (polyesters, -amides, -ethers, -carbonates, -urethanes) have also been studied much... 

The amide functionality plays an important role in the physical and chemical properties of proteins and peptides, especially in their ability to be involved in the photoinduced electron transfer process. Polyamides and proteins are known to take part in the biological electron transport mechanism for oxidation-reduction and photosynthesis processes. Therefore studies of the photochemistry of proteins or peptides are very important. Irradiation (at 254 nm) of the simplest dipeptide, glycylglycine, in aqueous solution affords carbon dioxide, ammonia and acetamide in relatively high yields and quantum yield (0.44)202 (equation 147). The reaction mechanism is thought to involve an electron transfer process. The isolation of intermediates such as IV-hydroxymethylacetamide and 7V-glycylglycyl-methyl acetamide confirmed the electron-transfer initiated free radical processes203 (equation 148). 

Amide group reduction probably occurs by the mechanism shown in Scheme 3. Two-electron transfer without protonation would give dianion 3. Elimination of LiNMe2 from 3 would give 4 (an acyl anion equivalent) and protonation of 4 at the carbonyl group would give benzaldehyde. 

The rate law for the oxidation of [Ru(NH3)5(FlL)] + (HE = isonicotinamide) by I2 in acidic solution contains two terms, one depending on P2] and one depending on [I3 ] and [Ru complex]. An outer-sphere electron-transfer mechanism is proposed for each term. Reduction of [Ru (NFl3)5L] + (TIL = nicotinamide or isonicotinamide) to [Ru (NH3)5L]+ is accompanied by an isomerization from the amide-bonded L to pyridine-bonded FIL. Bromine oxidation of... 

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