Amides general structure

Poly(amide-imide) is the condensation polymer of 1,2,4-benzenetricarboxylic anhydride and various aromatic diamines and has the general structure ... 

The C-6 carboxamide analogues of zanamivir, represented by the general structure 24, provided an avenue to introduce more hydrophobic side-chains onto the dihydropyran scaffold to interact with the hydrophobic regions of subsites S4 and S5 (reviewed in Islam and von Itzstein 2007). The most active tertiary amides (24 = alkyl) showed comparable inhibitory activity to their glycerol side-... 

Phosphinous amides of general structure R R PNHR are easily converted to their respective anions by metals or bases. For instance, they can be easily deprotonated by alkyllithium reagents to give the [R R PNR ] anions (8-A or 8-B, illustrated in Scheme 12). 

Fatty acid and unsaturated fatty acid mono- and diethanolamides Fatty acid mono- (FAMA) and diethanol amides (FADA) with the general formula (C,32n+1-C(0)N(HyCH2-CH2-0H)2 x = l or 0) are presented with their general structural formulae in Fig. 2.9.28(a) and (b). These surfactants have found a widespread application in household and personal care formulations because of their quite good... 

Deprotonation of a dihydrothiazine ring, followed by a reaction with an electrophile, is most straightforward in benzothiazin-3-ones (general structure 35), which are deprotonated at the 2-position by lithium diisopropyl amide (LDA). The enolate can then react with a variety of electrophiles including deuterium oxide, methyl iodide, and aldehydes <1982T3059>. Compound 70 was prepared in this manner from 2,4-dimethyldihydro-l,4-benzothiazin-3-one (Equation 27) <1985T569>. 

Prior to the previous edition of this book, no examples of substituted strontium amides had been well characterized. Even now, only a few strontium amide crystal structures are known and have been briefly reviewed in the context of more general aspects of the chemistry of group 2 metal compounds. ... 

A strong carbonyl absorption is evident in the spectra of all amides, although the frequency of absorption varies somewhat with the structure of the amide. Thus primary amides generally absorb near 1680 cm 1, whereas secondary and tertiary amides absorb at slightly lower frequencies. The N—H stretching frequencies of amides are closely similar to those of amines and show shifts of 100 cm-1 to 200 cm 1 to lower frequencies as the result of hydrogen bonding. Primary amides have two N—H bands of medium intensity near 3500 cm 1 and 3400 cm 1, whereas secondary amides, to a first approximation, have only one N—H band near 3440 cm 1. However, a closer look reveals that the number, position, and intensity of the N—H bands of mono-substituted amides depend on the conformation of the amide, which can be either cis or trans ... 

Note that the carbonyl assignments above are for carbamate salts with the general structure RNHC02 RNHj. In the case of ammonium carbamate, R=H. These carbamate salts should be distinguished from urethanes, which are carbamate esters, RNHCO,R. For urethanes, the carbamate bands are a combination of the amide and ester absorptions. The carbonyl stretch band shifts to about 1695 cm 1, a position between that of the normal ester and amide. The NH and NH2 stretch bands remain essentially unaltered as in corresponding... 

The amide anion formed (-NH-) is immediately neutralized by reaction (a), so that this disproportionation (b) results in the formation of a primary amine and an N-alkylimide of the general structure Rx CO-N-COR2... 

A number of C-6 carboxamide analogues were prepared in which the stereo-chemically complex glycerol side-chain of Zanamivir or 4-amino-4-deoxy-Neu5Ac2en was replaced entirely by secondary or tertiary amides with the general structure of 94 or 95.95,96 These series of compounds were prepared from the C-6 carboxylate 92 (prepared by periodate oxidation of the glycerol side-chain of 91) by amide couling via the activated pentafluorophenyl ester 93 (Scheme 3). 

The key intermediates in the synthesis of isoquinolines are 3-arylethylamines. For instance, acylation of P-phenylethylamine 6.11 gives amides of general structures 6.12 which can be cyclised with phosphorus oxychloride to produce dihydroisoquinoline 6.13. Better yields are obtained... 

Of interest are also substituted ethers of orthosilicon acid with an amide group in the organic radical, which have the following general structure ... 

A significant number of amide pesticides have a general structure of the type... 

Fig. 3.9 Compounds of the general structure 35 and the optimized structure 36 are protein kinase C (PKC) inhibitors. The introduction of an amide residue led to mixed PKC and bcr-abl kinase inhibitors 37, which lost their PKC-inhibitory activity by introduction of a...

Amide (Sections 20.1, 22.1) Acompxjund having the general structure RCONR 2 where R = H or alkyl. 

Carboxylic acid derivatives (Section 20.1) Compounds having the general structure RCOZ, which can be synthesized from carboxylic acids. Common carboxylic acid derivatives include acid chlorides, anhydrides, esters, and amides. 

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