Amalgamated magnesium

Acetone is reduced by amalgamated magnesium largely to a bimolecu lar reduction product, tetramethylethylene glycol or plnacol (CHjjjClOHjClOHjiCHj), some isopropyl alcohol is also formed ... 

Treatment of dihalogeno aromatics with lithium amalgam, magnesium, zinc, etc.,... 

In the same year, Rausch and co-workers found that the reductive carbonylation of (Tj-QMes ZrC in THF using amalgamated magnesium powder gave high yields of (rj-C5Me5)2Zr(CO)2 (30) (80%) under mild reaction conditions (59,62). The low pressure employed, together with the... 

Another interesting example of the Barbier reaction is that of 3-butylpyridine with aliphatic ketones in the presence of amalgamated magnesium [40]. With ethyl methyl ketone, 5-butyl-a-ethyl-a-methyl-2-pyridine methanol is isolated, in 70% yield. The corresponding a,a-dimethyl derivative is isolated when acetone is used as the ketone source. The ketyl-coupling products, R,R C(OH)-C(OH)R,R, are also produced in both reactions. 

Di- and trigermanes have been synthesized in 73-75% yields by the Wurtz-type-coupling reactions of phenyl chlorogermane or phenyl dichlorogermane with amalgamated magnesium [82]. 

Aluminum amalgam, 7, 275 Aluminum bromide, 7 Aluminum chloride, 6, 7-9, 49, 295, 299 Aluminum hydride, 9-10, 46 Aluminum isopropoxide, 10 Amalgamated aluminum, 7 Amalgamated magnesium, 7 Amidation, 17 Amides, 23, 147, 277 1-Aminoadamantanes, 295 (3-Amino alcohols, 162 p-Aminobenzaldehyde, 272 2,2 -Aminobenzophenones, 166... 

Pinacol reduction. Pinacol reduction is generally carried out with amalgamated magnesium or aluminum in benzene. Schreibmann1 reports that higher yields are obtained with amalgamated aluminum in either methylene chloride or THF, in which the aluminum pinacolates are very soluble. They are thus easily separated from excess metal before hydrolysis to the pinacol. 

Emmert and Asendorf showed that when ketones were heated with pyridine and amalgamated magnesium or aluminium, 2- and 4-hydroxy-alkylpyridines resulted. The yields from the reaction are moderate to good, and it has been used preparatively (the literature is summarized ). 

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