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Alzheimer’s amyloid precursor

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., et al. (1999). Beta-secretase cleavage of Alzheimer s amyloid precursor protein by the transmembrane aspartic protease BAGE. Science 286, 735—741. [Pg.282]

Rogers, J.T., Randall, J.D., Cahill, C.M., Eder, P.S., et al. (2002) An iron-responsive element type II in the 5 -untranslated region of the Alzheimer s amyloid precursor protein transcript, J. Biol. Chem., 277, 45518-45528. [Pg.320]

Vassar, R., Bennet, B.D., Babu-Khan, S., et al. (1999) P-Secretase cleavage of Alzheimer s amyloid precursor protein by the transmembrane aspartic protease BACE. Science, 286, 735-741. [Pg.331]

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, File J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G Citron M. (1999) Beta-secretase cleavage of Alzheimer s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 735-741. [Pg.392]

Antigen unmasking on sections of paraffin-embedded tissues can be accomplished by reduction of disulfide bonds by treatment with 2-mercaptoethanol, followed by alkylation with sodium iodoacetate to prevent the bonds from reforming. This method has been used for unmasking a Kunitz protease inhibitory domain epitope of Alzheimer s amyloid precursor protein in human brain (Campbell et al., 1999). Sections are reduced with a mixture of 0.14 M 2-mercaptoethanol in 0.5 M Tris-HCl (pH 8.0) and 1 mM EDTA for 3 hr in the dark at room temperature. After being washed for 3 min in distilled water, the sections are treated with a mixture of 250 mg/ml iodoacetic acid in 0.1 M NaOH, diluted 1 10 in 0.5 M Tris-HCl (pH 8.0) and 1 mM EDTA for 20 min in the dark. [Pg.191]

Campbell, E., Pearson, R. C. A., and Parkinson, D. 1999. Methods to uncover an antibody epitope in the KPI domain of Alzheimer s amyloid precursor protein for immunohistochemistry in human brain. J. Neurosci. Methods 93 133-138. [Pg.310]

Lammich S, Kojro E, Postina R, et al. Constitutive and regulated alpha-secretase cleavage of Alzheimer s amyloid precursor protein by a disintegrin metallopro-tease. Proc Natl Acad Sci USA 1999 96 3922-3927. [Pg.477]

Fig. 3.4 The structure of a PTB domain that recognizes the internalization motif of Alzheimer s amyloid precursor protein, p-APP. Fig. 3.4 The structure of a PTB domain that recognizes the internalization motif of Alzheimer s amyloid precursor protein, p-APP.
A human PTBdomain fragment of Xll is shown that binds to a 14mer peptide of the internalization iTKitif of the Alzheimer s amyloid precursor protein ((J-APP). Please note that the peptides are... [Pg.37]

Zh. Zhang, Ch-H. Lee, V. Mandiyan, J.-P. Borg, B. Margolis, J. Schlessinger, and J. Kuryan. Sequence-specific recognition of the internalization motif of the Alzheimer s amyloid precursor protein by the XI1 PTB domain. EMBOJ, 16, 6141 6150, 1997. [Pg.53]

DIFFERENTIAL EPITOPE IDENTIFICATION OF ANTIBODIES AGAINST INTRACELLULAR DOMAINS OF ALZHEIMER S AMYLOID PRECURSOR PROTEIN USING HIGH RESOLUTION AFFINITY-MASS SPECTROMETRY... [Pg.339]

Differential Epitope Identification of Antibodies Against Intracellnlar Domains of Alzheimer s Amyloid Precursor... [Pg.400]

Long JM, Lahiri DK (2011) Current drug targets for modulating Alzheimer s amyloid precursor protein Role of specific micro-RNA species. Curr Med Chem 18 3314-3321... [Pg.527]

M. A. Jarosinski, A. L. Biere, E. Curran, T. Burgess, J. C. Louis, F. Collins, J. Treanor, G. Rogers, M. Citron, beta-Secretase Cleavage of Alzheimer s Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE. Science. 1999, 286, 735-741. [Pg.248]

Rammes G, Rupprecht R, Fetrati U, Zieglgansbetger W, Parsons CG (2001) The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and NlE-115 cell systems in a non-competitive manner. Neurosci Lett 306 81-84 Ray B, Baneijee PK, Geig NH, Lahiri DK (2009) Memantine treatment decreases levels of secreted Alzheimer s amyloid precursor protein (APP) and amyloid beta (Abeta) peptide in the human neuroblastoma cells. Neurosci Lett [Epub ahead of print]... [Pg.378]


See other pages where Alzheimer’s amyloid precursor is mentioned: [Pg.292]    [Pg.277]    [Pg.627]    [Pg.692]    [Pg.732]    [Pg.150]    [Pg.215]    [Pg.248]   
See also in sourсe #XX -- [ Pg.152 , Pg.153 ]




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