Alphal-antitrypsin

L. Wright, and A. Churg. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alphal-antitrypsin. Am J Respir Cell Mol Biol 2000 22(2) 244-252. [Pg.342]

Kwon, K.S., and M.H. Yn, Effect of glycosy-lation on the stability of alphal -antitrypsin toward urea denaturation and thermal deactivation. Biochim Biophys Acta, 1997. 1335(3) 265-72. [Pg.62]

S. Rosenberg, P. J. Bair, R. CL Najarian, and R. A. HallewelL Synthesis in yeast of a fmotional oxidation-resistant mutant of human alphal-antitrypsin. Nature 3i2 TJ... [Pg.330]

Novoradovskaya N, Lee J, Yu ZX, Ferrans VI, Brantly M. Inhibition of intracellular degradation increases secretion of a mutant form of alphal-antitrypsin associated with profound deficiency. J. Clin. Invest. 1998 101 2693-2701. [Pg.2270]

Marcus NY, Perknutter DH. Glucosidase and mannosidase inhibitors mediate increased secretion of mutant alphal antitrypsin Z. J. Biol. Chem. 2000 275 1987-1992. [Pg.2270]

Takubo Y, Guerassimov A, Ghezzo H, Triantafillopoulos A, Bates JH, Hoidal JR, Cosio MG. Alphal-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice parallels with human disease. Am. J. Respir. Crit. Care Med. 2002 166 1596-1603. [Pg.2312]

Perlmutter, D.H. Alphal-antitrypsin deficiency. Curr. Treat. Option. Gastroenterol. 2000 3 451-456... [Pg.629]

Vemuri, S. Yu, C.-D. Roosdorp, N. Effect of cryoprotec-tants on freezing, lyophilization and storage of lyophilized recombinant alphal-antitrypsin formulations. PDA J. Pharm. Sci. Technol. 1994, 48, 241-246. [Pg.1654]

De BP, Heguy A, Hackett NR, Perris B, Leopold PL, Lee J, Pierre L, Gao G, Wilson JM, Crystal RG. High levels of persistent expression of alphal-antitrypsin mediated by the nonhuman primate serotype rh.lO adeno-associated virus despite preexisting immunity to common human adeno-associated viruses. Mol Ther 2006 13 67-76. [Pg.79]

M. Courtney, A. Buchwalder, L.-H. Tessier, M. Jaye, A. Benavente, A. Balland, V. Kohli, R. Lathe, P. Tolstoshev, and J.-P. Lecocq. High-level production of biologically active human alphal-antitrypsin in Escherichia coli. Proc. Natl. Acad. Sci. USA 81 669 (1984). [Pg.330]

Lomas DA, Parfrey H. Alphal-antitrypsin deficiency. 4 Molecular pathophysiology. Thorax, 2004 59(6) 529-535. [Pg.890]

Brigham K L, et al. (2000). Transfection of nasal mucosa with a normal alphal-antitrypsin gene in alphal-antitrypsin-deficient subjects comparison with protein therapy. Hum. Gene Ther. 11 1023-1032. [Pg.1050]

Lupi, A., Viglio, S., Luisetti, M., Gonini, M., Coni, R, Faa, G, Cetta, G, and ladarola, P. Alphal-antitrypsin in serum determined by capillary isoelectric focusing. Electrophoresis, 21, 3318, 2000. [Pg.808]

Qu D, Teckman JH, Omura S, Perlmutter DH (1996) Degradation of a mutant secretory protein, alphal-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity. J Biol Chem 271 22791-22795... [Pg.53]

B. Gooptu, U. I. Ekeowa, and D. A. Lomas, Mechanisms of emphysema in alphal-antitrypsin deficiency molecular and cellular insights, Eur. Respir. J. 34, 475-488 [2009). [Pg.514]

GLASSIA Alphal-Proteinase Inhibitor (Human) Treatment of chronic augmentation and maintenance therapy in individuals with emphysema due to congenital deficiency of alpha-1-proteinase inhibitor (alpha 1-PI), also known as alphal-antitrypsin 125325/0 Kamada Ltd. Beit Kama, 7 Sapir St Kiryat Weitzmann, Science Park P.O. Box 4081 Ness Ziona 74140 Israel License 1826 7/1/2010... [Pg.221]

Stockley RA. Exploring the role of CT densitometry a randomised study of augmentation therapy in alphal-antitrypsin deficiency. Eur Respir J 2009 33(6) 1345-53. [Pg.525]

Targeted gene correction of alphal-antitrypsin deficiency in induced... [Pg.305]

Ralston DR, Marsh CB, Lowe MP, et al. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alphal-antitrypsin, and Fcgamma receptors. J Clin Invest 1997 100(6) 1416-1424. [Pg.603]

Gaensler EA, Goff AM, Prowse CM (1966) Desquamative interstitial pneumonia. N Engl J Med 274 113-128 Gishen P, Saunders AJS, Tobin MJ, Hutchinson DCS (1982) Alphal-antitrypsin deficiency the radiological features of pulmonary emphysema in subjects of Pi type Z and Pi type SZ. A survey hy the British Thoracic Association. Clin Radiol 33 371-377... [Pg.174]

O Neal WK, Zhou H, Morral N, et al. Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alphal-antitrypsin after systemic delivery. Hum Gene Ther 1998 9 1587-1598. [Pg.48]

Morral N, Parks RJ, Zhou H, et al. High doses ofa helper-dependent adenoviral vector yield suptaphysiological levels of alphal-antitrypsin with negligible toxicity. Hum Gene Ther 1998 9 2709-2716. [Pg.49]

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