Alpha-tocopherol deficiency

Nickander KK, Schmelzer JD, Rohwer DA. Low PA. Effect of alpha-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve. J Neurol Sci 1994 126 6-14. 

Mardones P, Strobel P, Miranda S, Leighton F, Quinones V, Amigo L, Rozowski J, Krieger M, and Rigotti A (2002) Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice. Journal of Nutrition 132,443-9. 

Harata N, Iwasaki Y (1995) Evidence for early blood-brain btirrier breakdown in experimental thiamine deficiency in the mouse. Metab Brain Dis 10(2) 159-174 Harper CG (1983) The incidence of Wernicke s encephalopathy in Australia A neuropathological study of 131 cases. J Neurol Neurosurg Psychiatry 46 593-598 Harper CG, Butterworth RF (1997) Nutritional and metabolic disorders. In Graham DI, Lantos PL (eds) Greenfield s neuropathology. Arnold, London, pp 601-655 Hayton SM, Kriss T, Wase A, Muller DP (2006) Effects on neural function of repleting vitamin E-deflcient rats with alpha-tocopherol. J Neurophysiol 95(4) 2553-2559 Hayton SM, MuUer DP (2004) Vitamin E in neural and visual function. Ann N Y Acad Sd 1031 263-270... 

Shaw, H. M., and Huang, C. (1998) Liver alpha-tocopherol transfer protein and its mRNA are differentially altered by dietary vitamin E deficiency and protein insufficiency in rats. J Sutr 128, 2348-54. 

The constituents of cigarette smoke can degrade beta-carotene (71,72), but the conclusion that smoking causes increased carotenoid metabolism demands the demonstration of raised carotenoid oxidation products. Moreover, the consistent observation of subnormal carotenoid concentrations but unchanged alpha-tocopherol concentrations (70) suggests that factors other than oxidative stress contribute to the relative carotenoid deficiency. 

Schuelke M, Mayatepek E, Inter M, Becker M, Pfeiffer E, Speer A et al. Treatment of ataxia in isolated vitamin E deficiency caused by alpha-tocopherol transfer protein deficiency. J Pediatr 1999 134 240-4. 

Hruba, F., Novakova, V. and Ginter, E. (1982) The effect of chronic marginal vitamin C deficiency on the alpha-tocopherol content of the organs and plasma of guinea pigs. Experientia 38 1454-1455. 

Copp, R.P., Wisniewski, T., Hentati, E, Larnaout, A., Ben Hamida, M., and Kayden, H.J., Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain. Res. 822 (1-2), 80-87, 1999. 

Traber, M.G., Sokol, R.J., Kohlschutter, A., Yokota, T., Muller, D.P., Dufour, R., and Kayden, H.J., Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin E deficiency, J. Upid. Res. 34 (2), 201-210, 1993. 

Gohil, K., Schock, B.C., Chakraborty, A.A., Terasawa, Y., Raber, J., Farese, RV., Jr., Packer, L., Cross, C.E., and Traber, M.G., Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein, Free Radio. Biol. Med. 35 (11), 1343-1354, 2003. 

Rausch F (1956) Anaphylaktischer Schock nach Folsaure. Ther Ggw 95 53-55 Reuter H, Hellriegel KP (1977) Vitamins. In Side effects of drugs, annual 1. Excerpta Medica, Amsterdam London New York, pp 274-280 Reuter HD, Hellriegel KP (1979) Vitamins. In Side effects of drugs, annual 3. Excerpta Medica, Amsterdam London New York, pp 298-309 Ring J (1978) RIST, PRIST, RAST und so weiter. Dtsch Med Wochenschr 103 365-368 Roe DA (1976) Drug-induced nutritional deficiencies. AVI, Westport, Conn Roed-Petersen J, Hjorth N (1975) Patch test sensitization from D,L-alpha-tocopherol (vitamin E). Contact Dermatitis 1 391-393... 

HENTATI, A., DENG, H. X., HUNG, W. Y, NAYER, M., AHMED, M. S., HE, X., TIM, R., STUMPE, D. A., SIDDIQUE, T. AHMED 1996. Human alpha-tocopherol transfer protein Gene structure and mutations in familial vitamin E deficiency. Ann Neurol, 39, 295-300. 

OGIER, N., KLEIN, A., DECKERT, V., ATHIAS, A., BESSEDE, G., LE GUERN, N., LAGROST, L. DESRUMAUX, C. 2007. Cholesterol accumulation is increased in macrophages of phospholipid transfer protein-deficient mice Normalization by dietary alpha-tocopherol supplementation. Arterioscler Thromb Vase Biol, 27, 2407-12. 

TERASAWA, Y, LADHA, Z., LEONARD, S. W., MORROW, J. D., NEWLAND, D., SANAN, D., PACKER, L., TRABER, M. G. FARESE, R. V., JR. 2000. Increased atherosclerosis in hyperhpidemic mice deficient in alpha-tocopherol transfer protein and vitdimnF. Proc Natl Accid Sci USA, 97, 13830-4. 

Yamagishi M, Osakab N, Takizawa T, Osawa T. Cacao liquor polyphenols reduce oxidative stress without maintaining alpha-tocopherol levels in rats fed a vitamin E-deficient diet. Lipids 2001 36(1) 67-71. 

The symptoms of vitamin E deficiency produced by artificial diets high in unsaturated fatty acids or observed in patients unable to absorb fat (sprue, fibrocystic disease of the pancreas) include low blood and tissue tocopherol levels, increased red blood cell fragility and shortened red blood cell life-span, and increased urinary excretion of creatine (the latter is indicative of muscle damage). Marked improvement in these conditions is noted following administration of alpha-tocopherol. 

Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M, Sokol R, Aral H, Inoue K, Mandel JL, and Koenig M (1995) Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nature Genetics 9 141-145. 

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