Amoxicillin Allopurinol

Allopurinol, amoxicillin/clavulanic acid, dicloxacillin, erythromycin derivatives, halothane, phenytoin, and trimethoprim/sul-famethoxazole... 

ALLOPURINOL AMOXICILLIN, AMPICILLIN Possible t risk of rash with amoxicillin and ampicillin (over 20% incidence in one study) Uncertain Reassure patients that the rash is unlikely to have clinical significance... 

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

T effects W probenecid, disulfiram, T risk of rash W/ allopurinol, effects OF OCP, effects W/ tetracyclines, chloramphenicol EMS See Amoxicillin Amphotericin B (Amphecin) [Antifungal/Pelyene Macrolide]... 

Drugs that are the most common cause of TEN are allopurinol, ampicillin, amoxicillin, carbamazepine, NSAIDs, phenobarbital, pentamidine, phenytoin (diphenylhydantoin), pyrazolones, and sulfonamides. 

A retrospective search through the records of 1324 patients, 67 of whom were taking allopurinol and ampicillin, found that 15 of them (22%) developed a skin rash compared with 94 (7.5%) of the patients not taking allopurinol. The types of rash were not defined. Another study found that 35 out of 252 patients (13.9%) taking allopurinol and ampicillin developed a rash, compared with 251 out of 4434 (5.9%) taking ampicillin alone. A parallel study revealed that 8 out of 36 patients (22%) taking amoxicillin and allopurinol developed a rash, whereas only 52 out of 887 (5.9%) did so when taking amoxicillin alone. ... 

A case report describes a patient who developed erythema multiforme shortly after starting amoxicillin and allopurinol and who was found to have both allopurinol hypersensitivity and type IV amoxicillin hypersensitivity. ... 

Two cases of DRESS have been reported after the use of amoxicillin in patients who had had similar previous reactions, one to carbamazepine and one to allopurinol [36 ]. The authors raised the possibility of cross-reactivity. 

Ben Fred] N, Aouam K, Chaabane A, Toumi A, Ben Rhomdhane F, Boughattas N, Chakroun M. H5ipersensitiv-ity to amoxicillin after drug rash with eosinophilia and systemic symptoms (DRESS) to carbamazepine and allopurinol a possible co-sensitization. Br J Clin Pharmacol 2010 70(2) 273-6. 

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