Allergic Potential of JP

If components of JP-8 are seen as foreign by the immune system, JP-8 exposure could produce an immune response that leads to allergic response. Symptoms depend on the route of exposure contact dermatitis after dermal exposure, rhinitis and asthma after inhalation, and vomiting or diarrhea after ingestion. If JP-8 components are systemic sensitizers, anaphylaxis, a life-threatening systemic allergic reaction, could occur following subsequent JP-8 exposure. Except for anaphylaxis, similar symptoms can result from a nonspecific inflammatory response to irritants that does not involve sensitization of the immune system. 

The murine local lymph node assay is one predictor of the skin-sensitization potential of chemicals (Basketter et al. 1996). When JP-8 was tested in the assay with CBA/Ca mice, a strain that shows increased responsiveness to 

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