Allergic airway inflammation treatment

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Finotto S, Glimcher L T cell directives for transcriptional regulation in asthma. Springer Semin Immunopathol 2004 25 281-294. Finotto S, De Sanctis GT, Lehr HA, et al Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med 2001 193 1247-1260. 

Wiedermann U, Herz U, Baier K, Vrtala S, Neuhaus-Steinmetz U, Bohle B, Dekan G, Renz H, Ebner C, Valenta R, Kraft D Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice. Int Arch Allergy Immunol 2001 126 68-77. 

Montelukast sodium is a leukotriene receptor antagonist that blocks the effects of specific leukotrienes in the respiratory airways, thereby reducing bronchoconstriction, edema, and inflammation. It is indicated in the prophylaxis and chronic treatment of asthma in patients 12 months and older and in relief of symptoms of seasonal allergic rhinitis in patients 2 years and older. 

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