Alkynes amines, palladium® chloride

The groups R2N and Cl can be added directly to alkenes, allenes, conjugated dienes, and alkynes, by treatment with dialkyl-V-chloroamines and acids. " These are free-radical additions, with initial attack by the R2NH- radical ion. " N-Halo amides (RCONHX) add RCONH and X to double bonds under the influence of UV light or chromous chloride. " Amines add to allenes in the presence of a palladium catalyst. ... 

A variety of triazole-based monophosphines (ClickPhos) 141 have been prepared via efficient 1,3-dipolar cycloaddition of readily available azides and acetylenes and their palladium complexes provided excellent yields in the amination reactions and Suzuki-Miyaura coupling reactions of unactivated aryl chlorides <06JOC3928>. A novel P,N-type ligand family (ClickPhine) is easily accessible using the Cu(I)-catalyzed azide-alkyne cycloaddition reaction and was tested in palladium-catalyzed allylic alkylation reactions <06OL3227>. Novel chiral ligands, (S)-(+)-l-substituted aryl-4-(l-phenyl) ethylformamido-5-amino-1,2,3-triazoles 142,... 

The (dipyridin-2-ylmethyl)amine-derived palladium(n) chloride complex 30 has been found to be a highly efficient catalyst for the synthesis of alkynes in water or in iV-methylpyrrolidone and of diynes in the absence of reoxidant <2005EJOC4073>. 

The activity of homogeneous catalysts tilso has been demonstrated Wiltan son s catalyst tns(tnphenylphosphine) rhodium chloride induces petfluoroalkyl iodides to add to olefins at 80 °C [10] (equation 10) Tetrakis(tnphenylphosphine)-palladium promotes the addition to both alkenes and alkynes in hexane [11] Amines and amine salts induce addition at 120-140 °C [12] (equation 11)... 

Alkynyl ketones. 1-Alkynes react with some acyl chlorides in the presence of Cul and this palladium complex and triethylaminc to form 2-alkynyl ketones. The reaction fails with acyl chlorides that react easily with the amine. Use of dimethylcarbamoyl chloride results in 2-alkynamides. 

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