Alkylresorcinol derivatives

Phenols e.g. -alkylresorcinol homologues [1] thymol derivatives [2] hydoxyanthraquinones [3] ratanhia ohenols [41 ... 

Since 1969 the existence of resorcinolic lipids has been demonstrated in microbial organisms [24]. Leprosols, are resorcinolic lipids derivatives which have been identified in Mycobacterium leprae. Later the occurrence of simple 5-alkylresorcinols has been demonstrated in strains of soil bacteria from Azotobacter [104-107] and Pseudomonas families [104-111]. Bacterial resorcinolic lipids have been thought to be related exclusively to the transformation of vegetative cells into their dormant forms, cysts [106]. However, our previous studies on other Azotobacter and Pseudomonas strains [107], as well as recent, unpublished data indicate the occurrence of resorcinolic lipids also in vegetative cells, non-... 

Bis-alkylresorcinols (Fig 4, structures 109-113 and 116-119) have been demonstrated in plant material [138,144,147,156] together with their cyclic derivatives (e.g., Fig 4, structures 114, 115). From Bolivian algae Metzger has isolated other oligomeric derivatives [191] (Fig 4, structures 124-126). 

Recent experimental data have also shown that resorcinolic lipids, including alkylresorcinols and their derivatives at a concentration level of micrograms/ml inhibit competitively the reverse transcriptase of mice leukemia viruses and avian myeloblastosis [338,339]. 

One of the most interesting studies of the effect of various alkyl groups on physiological activity is illustrated by the alkyl derivatives of resorcinol, which are discussed under Hexylresorcinol. The bactericidal action at first increases with the length of the side chain and then diminishes because of decreased solubility of the alkylresorcinol. Coincident with this increase is found a decrease in toxicity. 

---