1- Alkylamino-2-phenyl

Amin- (chirale) Vl/lb, 248 Amin-cyan-dihydro- XIII/3b, 501 Amino-diaryl- XIII/3b, 71 Aryl-benzyl-chlor- XIII/3a, 398 Aryl-bis-[2,4,6-trimethyl-phenyl]-XIII/3a, 167 Aryl-dijod- XIII/3a, 465 Azido-diorgano- XIII/3b, 114 Bis-[alkylamino]-phenyl- XIII/3b,... 

Irradiation of 3-[o-(alkylamino)phenyl]-5-methyl-l,2,4-oxadiazole 1507 leads to concomitant formation of benzimidazoles 1509 and indazoles 1508, presumably arising from a common photolytic species, as shown in Scheme 390 <1996JOC8397>. 

Jhh and " Jhh couplings have been measured by Katrizky et al for re-gioisomeric 3-[2- or 5-anilino-2-(alkylamino)phenyl]propanoic acids, 2H-1,4-benzothioazin-3(4/f)-ones and 2,3-dihydro-l,5-benzothiazepin-4(5if)-ones, by Suri et for a series of pyrido[l,2-a]pyrimidine derivatives, and by Laatsch and co-workers for helquinoline, a new tetrahydroquinoline antibiotic isolated from Janibacter limosus. The configuration around the double bonds and the epoxide stereochemistry of oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp., has been established on the basis of Vhh by Hayakawa et... 

Substituted imidazo/benzimidazo[2,l- ]quinazolinones could be synthesized from (l//-imidazol-l-yl)[2-(alkylamino)phenyl]methanones and (l//-benzimidazol-l-yl)[2-(alkylamino)phenyl]-methanones catalyzed by CuCl in the absence of hgand using air as the oxidant (Scheme 8.105). The method is tolerant toward functional groups in the substrates, and a range of 5-substituted imidazo/benzimidazo[2,l- ]quinazolinones could be obtained in moderate to good yields. A C(sp )-H bond was activated to form a new C-N bond [179]. 

Cinnoline, 4-alkylamino-3-phenyl-tautomerism, 3, 5 Cinnoline, 4-amino-biological aaivity, 3, 56 nitration, 3, 21 tautomerism, 3, 5 Cinnoline, dihydro-... 

Pyrimidine, 5-benzyl-4,6-dimethyl-2-phenyl-synthesis, 3, 118 Pyrimidine, 2-benzyl-5-nitro-synthesis, 3, 130 Pyrimidine, benzyloxy-pyrimidinone synthesis from, 3, 133 Pyrimidine, 4,5-bis(alkylamino)-synthesis, 3, 121 Pyrimidine, 2-bromo-aminolysis, 3, 100 H NMR, 3, 62 reactions... 

Other non-traditional preparations of 1,2,3-triazoles have been reported. The rearrangement in dioxane/water of (Z)-arylhydrazones of 5-amino-3-benzoyl-l,2,4-oxadiazole into (2-aryl-5-phenyl-27/-l,2,3-triazol-4-yl)ureas was investigated mechanistically in terms of substituents on different pathways <06JOC5616>. A general and efficient method for the preparation of 2,4-diary 1-1,2,3-triazoles 140 from a-hydroxyacetophenones 139 and arylhydrazines is reported <06SC2461>. 5-Alkylamino-] //-], 2,3-triazoles were obtained by base-mediated cleavage of cycloadducts of azides to cyclic ketene acetals <06S1943>. Oxidation of N-... 

Dimethyl-3-(2-oxo-2-phenyl-ethyl--bromid lagert sich beim Kochen mit Triethylamin in Acetonitril in 2-(2-Imino-5-phenyl-2,3-dihydro-oxazol-3-yl)-4,6-dimethyl-pyrimidin um. Aus diesem werden durch Kochen in Alkoholen mit 4-Methyl-benzolsulfonsaure als Katalysator 2-Alkoxy-l-(4,6-dimethyl-2-pyrimidyl)-4-phenyl-imidazole oder durch Erhitzen mit primaren oder sekundaren Aminen ebenfalls in Gegenwart von 4-Methyl-benzolsulfonsaure 2-Alkylamino-l-(4,6-dimcthyl-2-pyrimidyl)-4-phe-nyl-imidazole erhalten374 ... 

Analog erhalt man mit Alkylaminen/Kalium-permanganat 4-Alkylamino-ptcridinc1, z.B. 4-Ethylamino-7-phenyl-pteridin (26%) und 4-tert.-Butylamino-7-phenyl-pteridin (70%),... 

Die gleichartige, reduktive C—C-Verknupfung von N-Alkyl-benzaldiminen durch akti-viertes Aluminium in Ethanol ergibt l,2-Bis-[alkylamino]-l,2-diphenyl-ethane (z.B. 1,2-Bis-[4-methoxy-phenyl]-l,2-bis-[methylamino]-ethan), die man durch Gegen-... 

Chapman and coworkers (79RTC334) from studies on the low temperature photolysis of phenyl azide in an argon matrix at 8 K produced convincing IR spectroscopic evidence for the formation of l-aza-l,2,4,6-cycloheptatetraene (217), rather than a benzazirine intermediate. In fact, these workers have reinterpreted the formation of 2-alkylamino-3ff-azepines on the basis of amine addition to the cumulated system (217) rather than the benzazirine. 

Buscemi, S., Vivona, N. and Caronna, T. (1995) A generalized and efficient synthesis of 3-amino-, 3-(N-alkylamino)-, 3-(N, N-dialkylamino)-5-alkyl-l, 2,4-oxadiazoles by irradiation of 3-alkanoylamino-4-phenyl-l, 2,5-oxadiazoles (furazans). Synthesis, (8), 917-919. 

Reactions of 1,2,4-thiadiazoles with radicals and electron deficient species are virtually unknown. Catalytic and dissolving metal reductions usually result in S—N bond cleavage. For example, the 5-anilino-3-hydroxy derivative (51) gives a good yield of l-phenyl-2-thiobiuret (52) on Zn-HCl reduction (Scheme 27). Reduction of the diamino derivative (53) gives amidinothiourea (54) from which it may be prepared by oxidation (Scheme 28). Under similar conditions, cleavage of the 3,5-diphenyl derivative (55) results in loss of sulfur and formation of benzylbenzamidine (56 Scheme 29). Reduction of 5-alkylamino-or 5-arylamino-3-alkylthio derivatives (57) with H2S in pyridine-triethylamine or sodium in liquid ammonia yields 1-substituted dithiobiurets (58 Scheme 30). 

Copper(II) acetate in refluxing methanol has been used to prepare 3-alkyl-5-methyl-6-phenyl-3,4-dihydro-l,2,3-triazin-4-ones 568 from 2-(alkylamino)-4-methyl-5-phenyl-l,2-dihydropyrazol-3-ones 567 (Scheme 256). Alternatively, this conversion may be achieved, albeit in a slow reaction, using airoxygen in the presence of sodium hydro-gencarbonate <2006EJ03021>. 

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