Alkaline hydrogen peroxide, role

More recently, the same group achieved a simple, highly stereocontrolled total synthesis of (+)-hirsutic acid (Scheme LXXIX) ". This chirally directed effort developed subsequent to reaction of dl-728 with (+)-di-3-pinanylborane, alkaline hydrogen peroxide oxidation, chromatography, PCC oxidation, and hydrogenolysis. The dextrorotatory hydroxy ketone 729 was nicely crafted into keto aldehyde 730 from which 720 was readily obtained. Once again, the Wacker oxidation played an instrumental role in annulation of the third five-membered ring. The remainder of the asymmetric synthesis was completed as before. 

Markovic NM, Tidswell IM, Ross PN. 1994. Oxygen and hydrogen peroxide reduction on the gold(lOO) surface in alkaline electrolyte the roles of surface structure and hydroxide adsorption. Langmuir 10 1-4. 

J.Y. Cho, H. Cui, J.H. Park, S.H. Yi, J.G. Park, Role of hydrogen peroxide in alkaline slurry on the polishing rate of polycrystalline Ge2Sb2Tes film in chemical mechanical polishing, Electrochem. Solid-State Lett. 13 (5) (2010) H155—H158. 

On the other hand. Chance (1952a) claimed an essential role for manganous ions, as indicated by the reported velocity constants reproduced in Table III. Under his conditions hydrogen peroxide could only partially replace the manganese. In the reaction with triose reductone, Yamazaki et al. (1956) show that manganese only produces an appreciable activation at alkaline pH values, where the peroxidase alone is almost inactive. They claim that the only extra component essential for oxidatic activity is hydrogen peroxide, a deficiency of which can be detected by an initial lag in substrate disappearance. 

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