Alginate-based scaffolds

Bhattarai N et al (2006) Alginate-based nanofibrous scaffolds structural, mechanical, and biological properties. Adv Mater 18(11) 1463—t... 

Alginate-poly(L-lysine)-alginate (APA) microcapsules were used to entrap EPO-secreting cells. Implantable and injectable hydrogel-based scaffolds containing the cells have been developed. The implantation of the cell-loaded capsules containing hydrogel-based scaffolds in mice revealed that hematocrit levels were maintained up to 80% for at least 2 months. 

To mimic the physiological barriers of cell migration in the tissue, natural or artificial scaffold matrix are incorporated inside the microfiuidic chip in a specific fashion as defined by the experimental studies. Collagen, Matrigel, alginate, and hyaluronic acid-based scaffolds are some of the examples that have been used for this purpose. The choice of scaffold matrix is largely... 

Ashtona RS, Banerjee A, Punyania S et al (2007) Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials 28 5518-5525... 

Polysaccharide-based polymers (eg, chitosan, starch, alginate, HA, dextran) show interesting properties such as good hemocompatibihty, good interactions with cells, nontoxicity and lower cost with respect to other biopolymers such as collagen, thereby justifying their use as scaffold materials in TE apphcations. 

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