Alcyonium paessleri

The Hawaiian sponge Hyrtios sp. from Oahu has furnished 21-chloropuupehe-nol (430), while the same sponge from Maui contains molokinenone (431) (619). The absolute configuration of these drimane-phenolic metabolites has been assigned as shown based on that of puupehenone (620). The South Georgia Island soft coral Alcyonium paessleri produces several novel illudalane sesquiterpenoids, including the chlorinated alcyopterosins A (432), D (433), K (434), and L (435) (621). 

Palermo JA, Brasco MFR, Spagnuolo C, Seldes AM (2000) Illudalane Sesquiterpenoids from the Soft Coral Alcyonium paessleri The First Natural Nitrate Esters. J Org Chem 65 4482... 

A similar assay was used to examine the effects of extracts from three soft corals Alcyonium paessleri, Clavularia frankliniana, and Gersemia antarctica, against three species of marine bacteria (Slattery et al. 1995). In this assay, replicate 20-g soft coral samples were extracted in 200 ml of solvent and then diluted to tissue level concentrations. Twenty-five microliters of each soft coral extract or a solvent control were then spotted onto glass microscope slide cover-slips. The coverslips were placed into individual wells of tissue culture plates that contained 2 ml of sterile-filtered seawater seeded with 50 Lil of a bacterial suspension (7.5 x 10 cells/ml). Following a 48-h incubation, the coverslips were washed with sterile-filtered seawater to remove unattached cells and stained with DAPI (4,6-diamidino-2-phenylindole). The number of cells in each of five replicate microscope fields per coverslip were counted using epifluorescence microscopy. Bacterial attachment was found in this study to be inhibited by the chloroform extracts of both A. paessleri and G. antarctica and the methanol extract of G. antarctica. The active chloroform extracts did not display antimicro-... 

Palermo, J.A., Brasco, M.F.R., Spagnuolo, C., and Seldes, A.M. (2000) Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri the first natural nitrate esters./. Org. Chem., 65, 4482-4486. 

An entirely new series of nitric esters of sesquiterpenes having the illudalane skeleton has been characterized in the Antarctic alcyonarian Alcyonium paessleri harvested in South Georgia at depths between 100 and 200 meters (Palermo et al, 2000). Alcyopterosins are thus the first... 

Rodriguez Brasco, M.F., Seldes, A.M., and Palermo, (,A, (2001) Paesslerins A and B novel tricyclic sesquiterpenoids from the soft coral Alcyonium paessleri. Org. Lett., 3,1415-1417,... 

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