Paracetamol alcohol interactions

This is known as Michaelis-Menten or saturation kinetics. The processes that involve specific interactions between chemicals and proteins such as plasma protein binding, active excretion from the kidney or liver via transporters, and metabolism catalyzed by enzymes can be saturated. This is because there are a specific number of binding sites that can be fully occupied at higher doses. In some cases, cofactors are required, and their concentration may be limiting (see chap. 7 for salicylate, paracetamol toxicity). These all lead to an increase in the free concentration of the chemical. Some drugs, such as phenytoin, exhibit saturation of metabolism and therefore nonlinear kinetics at therapeutic doses. Alcohol metabolism is also saturated at even normal levels of intake. Under these circumstances, the rate of... 

The paracetamol-alcohol interaction is complex acute and chronic ethanol intake has opposite effects. 

As with alcohol, there is a complex interaction between isoniazid and paracetamol, affecting the risk of hepatotoxicity [5]. 

The FDA has announced its intention to require alcohol warnings on all over-the-counter pain medications that contain acetylsalicylic acid, salicylates, paracetamol, ibuprofen, ketoprofen, or naproxen. The proposed warnings are aimed at alerting consumers to the specific risks incurred from heavy alcohol consumption and its interaction with analgesics. For products... 

The sedative effects of tizanidine and other sedative drugs and alcohol are additive. Increased bradycardia might occur with dig-oxin. It is unclear whether tizanidine prolongs the QT interval in humans. No interaction occurs with paracetamol (acetaminophen). 

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