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Albumin gene delivery

Rhaese, S., von Briesen, FI., Rubsamen-Waigmann, FI., Kreuter, J., and Langer, K. (2003), Human serum albumin-polyethylenimine nanoparticles for gene delivery, J. Controlled Release, 92(1-2), 199-208. [Pg.558]

Shohet RV, Chen S, Zhou YT, Wang Z, Meidell RS, Unger RH, Grayburn PA (2000) Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 101 2554-2556... [Pg.485]

Lu W, Sun Q, Wan J, et al. Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administration. Cancer Res 2006 66 11878-11887. [Pg.489]

Polycationic Serum Albumin Proteins for Gene Delivery. 218... [Pg.212]

Fig. 4 Top Cationization of the protein human serum albumin carrying multiple positively charged primary amino groups. Images show that such albumin polycations (stained red) reveal efficient cellular uptake by clathrin-mediated endocytosis, endosomal release (yellow arrows), and allow gene delivery and release into cells due to tight interaction of DNA, as exemplified by the isothermal titration calorimetry graph... Fig. 4 Top Cationization of the protein human serum albumin carrying multiple positively charged primary amino groups. Images show that such albumin polycations (stained red) reveal efficient cellular uptake by clathrin-mediated endocytosis, endosomal release (yellow arrows), and allow gene delivery and release into cells due to tight interaction of DNA, as exemplified by the isothermal titration calorimetry graph...
Serum albumin has also been tested as NPs for gene delivery. Mo et al. [88] encapsulated the DNA into human serum albumin (HSA) by a desolvationcrosslinking method to produce DNA-HSA NPs having a mean size of 120 nm and zeta potential of —44 mV. The DNA-HSA NPs were easily taken up by the cells via receptor-mediated endocytosis that involved primarily caveolae pathways. Within the cells, DNA-HSA NPs protected the DNA against nuclease attack and showed sustained release of DNA over 6 days without significant cytotoxicity. The overall transfection rate was found to be fivefold higher than obtained with Lipofectamine. [Pg.64]

Fischer, D., Bieber, T., Brusselbach, S., etal. (2001) Cationized human serum albumin as anon-viral vector system for gene delivery Characterization of complex formation with plasmid DNA and transfection efficiency, Int. J. Pharm., 225, 97-111. [Pg.84]

Nitta, S. and K. Numata, Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering. International Journal of Molecular Sciences, 14 (1) 1629-1654,2013. Kummitha, C.M., A.S. Malamas, and Z.R. Lu, Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles. International Journal of Nanomedicine, 7 5205-5214,2012. [Pg.263]

Abstract This chapter summarizes the influence of polyelectrolyte topology oti biological functions and biomedical applications such as cell uptake, drug delivery, and gene transfection. Polyelectrolytes utilized are spherical structures derived from dendrimers and albumin or cylindrical brushes, all of which are decorated with various polypeptide chains. [Pg.211]

Mo Y, Barnett ME, Takemoto D et al (2007) Human serum albumin nanoparticles fw efficient delivery of Cu, Zn superoxide dismutase gene. Mol Vis 13 746-757... [Pg.82]

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See also in sourсe #XX -- [ Pg.218 ]



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