Alanine conjugate acid

The biological activity of the aspartic acid and alanine conjugates of lAA was directly related to the ease of hydrolysis of the amino acid conjugates in a bean stem assay. The aspartic acid conjugate was more resistant to hydrolysis and relatively inactive compared to the alanine conjugate The aspartic acid conjugate of NAA was... 

Following are structural formulas for propanoic acid and the conjugate acids of isopropylamine and alanine, along with p values for each functional group. 

A more challenging problem is to find the pH of a solution prepared from a polyprotic acid or one of its conjugate species. As an example, we will use the amino acid alanine whose structure and acid dissociation constants are shown in Figure 6.11. 

Fig. 3.15 Model for allosteric inhibition of a protein-DNA complex by a polyamide-inter-calator conjugate. (Top) The GCN4 homodimer (yellow) is displaced by the intercalating moiety (green) of the polyamide conjugate. Blue and red spheres represent pyrrole and imidazole amino acids, respectively. The blue diamond represents / -alanine. (Bottom, left) Hydrogen-bonding model of an eight-ring hairpin polyamide-intercalator conjugate...

Recently, chloromethylated benzocoumarin 11c, hydroxylmethylated benzocou-marin 12, and chloromethylated coumarin 13 were used in the efficient preparation of several fluorescent ester conjugates of /V-benzyloxycarbonyl-neurotransmitter amino acids, such as p-alanine, tyrosine, 3,4-dihydroxyphenylalanine (DOPA), glutamic acid, and y-aminobutyric acid (GABA) [39, 40],... 

The amounts of single amino acids excreted in urine in the conjugated form, as determined independently by Stein and Muting, are given in Tables 1 and 2. According to Stein, glycine, glutamic acid, aspartic acid, histidine, and proline are quantitatively the most important amino acids liberated in the course of urine hydrolysis. Serine, lysine, tyrosine, cysteine and cystine, threonine, alanine, valine, phenylalanine, and leucine are... 

The catalytic efficiency of this enzyme to hydrolyze 5-fluoro-5,6-dihydro-uracil was found to be approximately twice that toward 5,6-dihydrouracil [152], 2-Fluoro-/3-alanine can either be eliminated via the bile after conjugation with bile acids, or be converted to fluoroacetate (4.238) [153], The latter metabolite is transformed to fluorocitrate, a potent inhibitor of the aconi-tase-catalyzed conversion of citrate to isocitrate. This inhibition probably explains the clinical neurotoxicity of 5-fluorouracil [154] [155],... 

D. J. Sweeney, S. Barnes, R. B. Diasio, Formation of Conjugates of 2-Fluoro-/3-alanine and Bile Acids during the Metabolism of 5-Fluorouracil and 5-Fluoro-2-deoxyuridine in the Isolated Perfused Liver , Cancer Res. 1988, 48, 2010-2014. 

Protein ALBP-PX was the first pyridoxamine-conjugated protein to be synthesized and structurally characterized. Under single-turnover conditions, this protein demonstrated amino acid production rates of only 56% of the free cofactor. However, depending on the nature of the a-keto acid, ALBP-PX did show a range of optical inductions for the amino acid product. Notably, enantiomeric excesses in the order of 94% were observed for the production of valine. Additionally, several trends were noted. All amino acid products that showed optical induction favored the 1-enantiomer, except alanine, which favored the d-enantiomer. Furthermore, a-keto acids with branched side chains... 

Plant. Amitrole is transformed in plants forming the conjugate p (3-amino-l,2,4-tria-zol-l-yl)-a-alanine (Humburg et ah, 1989) and/or 3-(3-amino-s-triazole-l-yl)-2-aminopropionic acid (Duke et al, 1991). Amitrole is metabolized in Canada thistle Cirsium arvense L.) to three... 

The main amino acids used to form the conjugates are glycine, glutamine, ornithine (birds), alanine (hamsters and mice), arginine and taurine. 

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