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Akt/protein kinase B

Brognard, J., Clark, A.S., Ni, Y., and Dennis. P.A. 2001. Akt/protein kinase b is constitutively active in nonsmall cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. [Pg.479]

An application of this synthetic strategy by the same group led to the development of a series of potent and selective allosteric Akt (protein kinase B/PKB) kinase inhibitors that induced apoptosis in tumor cells and inhibited Akt phosphorylation in vivo (Scheme 6.261) [451]. [Pg.270]

Akama, K. T. and McEwen, B. S. Estrogen stimulates post-synaptic density-95 rapid protein synthesis via the Akt/ protein kinase B pathway. /. Neurosci. 23 2333-2339,2003. [Pg.858]

Carson, J.P., KuUk, G., Weber, M.J. 1999, Antiapoptotic signaling in LNCaP prostate cancer cells a survival signaling pathway independent of phosphatidylinositol 3 -kinase and Akt/protein kinase B. Cancer Res Apr 59 1449-1453... [Pg.327]

Triciribine, also known as Akt/protein kinase B signaling inhibitor-2 (API-2) compound 52, Fig. 9), was identified by screening the National Cancer Institute Diversity Set chemical library (1992 compounds). The screen was performed using a cell-based proliferation assay with PKB/1 transformed NIH3T3 cells, and triciribine scored positive in this assay with an IC50 value of 50 nM [ 196]. Although the compound blocks the cellular phosphorylation... [Pg.197]

Tremblay, R Lavigne, C. Jacques, H. Marette, A. Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (z/1) activities. Diabetes, 50, 1901-1910 (2001)... [Pg.187]

Ushio-Fukai, M., Alexander, R. W., Akers, M., et al. 1999b. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem 274 22699-22704. [Pg.114]

Gorin Y, Ricono JM, Kim NH, Bhandari B, Choudhury GG, Abboud HE. 2003. Nox4 mediates angiotensin Il-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 285 F219-F229. [Pg.224]

Takahashi T, Taniguchi T, Konishi H, Kikkawa U, Ishikawa Y, Yokoyama M. 1999. Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells. Am J Physiol 276 H1927-H1934. [Pg.227]

Whiteman EL, Cho H, Birnbaum MJ. 2002. Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab 13 444-451. [Pg.228]

Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC, Franke TF, Marsh CB. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem 1999 274(37) 26393-8. [Pg.2196]

Kaushal GP, Kaushal V, Flong X, Shah SV. Role of caspases and their regulation by Akt/protein kinase B phosphorylation pathway in cisplatin-induced injury to renal tubular epithelial cells. Kidney Int 2001 60 1726-1736. [Pg.168]


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See also in sourсe #XX -- [ Pg.354 ]




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Akt kinase

Akt/protein kinase

B PROTEINS

Kinases AKT/protein kinase B

Protein kinase B

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