Ajuga

Ajuga chia (Labiatas). In this haemostatic drug the presence of alkaloids has been recorded by Aliev. (Farmatsiya, 1946, 9, 21 Chem. Abstr., 1948, 42, 287.)... 

Konoshima, T. et al.. Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, fvom Ajuga decumbens. Cancer I tt., 157, 87, 2000. 

Keywords Ajuga postii, bioactive constituents, cytotoxic activity, DNA damaging... 

Juglans regia L. Lamiaceae (Labiatae) Ajuga bombycina Boiss. -21.4 49.0 28.4... 

Fig. 6.2 Diterpenes isolated from Ajuga cliamaepytis ssp. laevigata...

Since DNA damaging activity resnlts didn t give almost no hit except a few extracts Ajuga and Juniperus) (Table 6.4) we directed onr bioactivity assay to ovarian cytotoxic activity search. 

Terahara, N. et al., Triacylated anthocyanins from Ajuga reptans flowers and cell cultures. Phytochemistry, 42, 199, 1996. 

Among the new anthocyanins, which have been reported after 1992, 47, 22, and 36 contain sophorose, rutinose, and sambubiose, respectively (Figure 10.5). Most of the anthocyanins containing sophorose were first isolated from species belonging to Convolvulaceae (22) and Cruciferae (13) (Table 10.2). This disaccharide has also been identified in new anthocyanins isolated from AJuga (Labiatae), " "" Consolida (Ranunculaceae)," Begonia (Begonia-ceae)," and in the flavonol unit of two covalent anthocyanin-flavonol complexes from Allium (Alliaceae)."... 

Madhavi, D.L. et al., Characterization of Anthocyanins from Ajuga pyramidalis Metallica Crispa cell cultures, J. Agric. Food Chem., 44, 1170, 1996. 

Observations In nature obviate the fact that certain plant species and cultlvars are more resistant to Insect attackl 3 than are others. Ajuga remota (Lablatae) Is an example of this. A survey of a Kenyan savannah following a locust attack revealed that the only vegetation to survive the assault was A. remote/. ... 

Figure 2. A molting cycle failure of the silkworm, Bombyx mori, caused by ingestion of the crude methanol extract of Ajuga remota root. The insect underwent normal apolysis, but failed to complete ecdysis. Thus, it could not remove its head capsule or its trunk exuviae. Magnification X11.

Figure 3. Electron micrograph of a fall armyworm, Spcxloptera frugiperda, after ingestion of the crude methanol extract of Ajuga remota roots. This insect has three head capsules that mask its functional mouthparts. The insect eventually starved to death. Magnification X.38.

In order to obtain sufficient quantities of these phytoecdysones for more detailed biological studies, droplet counter-current chromatography (DCCC) was adapted . DCCC Is an especially efficient method for the preparative separation of polar compounds like the phytoecdysones. Thus with DCCC, while requiring only small volumes of solvent, more than 50 mg of each of the Ajuga phytoecdysones were rapidly and nondestructlvely separated and fully recovered (Fig. 6) from each 500 mg Injection. 

Figure 6. DCCC of the ethyl acetate extract of Ajuga remota (500 mg) with CHCI, -MeOH-HjO (13 7 4) by the ascending method.

N.A. Ajuga reptans L. Indoid glycosides (harpagide).99 An astringent, mild analgesic, laxative. 

Pittosporum tobira (Thunb.) Aiton Cibotium barometz (L.) J. Smith Ajuga bracteosa Wallich, A. decumbens Rhodiola elongata (Ledeb.) Fisch. Meyer Aster ageratoides Plumeria rubra L. 

Arthraxon hispidus (Thunb.) Makino Ajuga pygmaea A. Gray... 

Ajugasterone Ajuga bracteosa, A. decumbens, A. pygmaea, Alangium lamarckii... 

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