Agonists morphine

Heroin, a synthetic derivative of the p opioid receptor agonist morphine, is a well-documented narcotic that alters mood and rewarding behaviors. To date, heroin is the most abused opioid with an estimated 750,000-1,000,000 hardcore users in the... 

Synthetic agonist Morphine Codeine Fentanyl Pethidine DSTBULET DPDPE U50488H Pentazocine Oxycodone ... 

Phenanthrenes (morphine-like agonists) Morphine (various) Naturally occurring ++ +... 

Interactions are seen between cocaine and the opioid system in analgesia. A synergistic effect occurs when cocaine is combined with a ju agonist (morphine) in the hot-plate test and a k agonist (U69,593) in the hot-plate test (Waddell and Holtzman 1999). Cocaine enhances morphine analgesia in several analgesic paradigms (e.g., formalin test, hot-plate test, and thermal tail-flick test)... 

Mu and kappa receptor agonists have been shown to affect central dopaminergic activity in rodents in vivo and in vitro [78, 79]. This has been investigated with RP 60180 (51), which decreases dopamine (DA) utilization in rat prefrontal cortex and in the striatum (by 30—35 % and 10 % respectively at 1-2.5 mg/kg s.c.) whereas the mu agonist morphine causes a significant increase (90-150% and 30 40% respectively at 5 mg/kg), an effect which is abolished by RP 60180 (1 2.5 mg/kg) [80]. 

Presynaptic Opioid Heteroreceptor Agonists Morphine and Related Drugs. 568... 

Figure 2.3 Dextromethorphan 6, the unnatural enantiomer of a narcotic morphine analog, is an antitussive drug. The antidiarrhea drug loperamide 7 and the neuroleptic drug haloperidol 8 also resulted from structural modification of morphine. The morphine antagonist nalorphine 9 differs from the opioid agonist morphine 3 (Figure 2.2) only by having an N-allyl group instead of the N-methyl group.

Agonists Morphine 10 mg and upwards Oral, subcutaneous, 2-4 Severe pain, anesthesia Sedation, constipation, nausea, vomiting. 

Fig. 7 Structures of opioid receptor ligands that have antitussive effects (agonists morphine, codeine, U-50,488H antagonists NTI), 8 opioid agonist DPDPE, and k opioid antagonist nor-BNI...

Full agonists morphine, meperidine, methadone, fentanyl, and heroin... 

Full agonists morphine, meperidine, methadone, fentanyl, and heroin Partial agonists buprenorphine, codeine, propoxyphene Mixed agonist-antagonists nalbuphine, pentazocine Antagonists naloxone, naltrexone Phenothiazines chlorpromazine, fluphenazine, thioridazine Others haloperidol, clozapine, risperidone, olanzapine... 

Strong agonists Morphine Heroin, meperidine, methadone Fentanyl. levorphanol... 

Figure 5.2. Comparison of log dose-response regression lines for the ct-adrenoceptor agonists, clonidine ( ), xylazine (a) and St-56 7 (o) vrith those of the narcotic agonist morphine (m) and the narcotic partial agonist pentazocine (o), using the mouse tail immersion test. Immersion temperature = 4(f C. The antinociceptive effect (%) was determined according to the method of Sewell [68,691...

Fio. 23. Structure foimulae of the agonists morphine and levorphanol. and of morphine-antagonists nalorphine and levalloiphan. For the morphine-like analgesic meperidine, the conventional (A) and adapted (B) formula is given. 

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