Pharmacology narcotic agonists

Pharmacology Nalbuphine is a potent analgesic with narcotic agonist and antagonist actions. Its analgesic potency is essentially equivalent to that of morphine on a milligram basis. 

Chemical and structural specificity Any alteration in the structure of a compound alters its pharmacologic properties. For example, nalorphine, a narcotic antagonist, differs from morphine, a narcotic agonist, by the replacement of the CH3 group on the morphine s nitrogen with the allyl radical -CH2CH=CH2. 

The inappropriate or illegal use and abuse of narcotics such as heroin is a major problem in many countries. Hence, various strategies have been employed to treat people who are addicted to heroin and other opioids. Methadone is the primary pharmacological intervention used to treat opioid addiction. Methadone is a strong opioid agonist, similar in potency and efficacy to morphine. While giving an opioid to treat an opi-... 

Furness SC, Zhang X, Coop A et al (2000) Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(aR)-alpha-(2S,5R)-4-substituted-2,5-dimethyl-l-piperazinyl-3-methoxybenzyl]-N, N-diethylbenzamides and their enantiomers. J Med Chem 43 3193-3196... 

Naloxone (XVlIa) Is t only reported narcotic antagonist without other biological activity. This can be demonstrated by an acetylcholine release assay which measures both agonist and antagonist actions of narcotics, as well as by pharmacological studies. In contrast, analogs... 

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