Agkistrodon venom

Arvin [9046-56-4] is a purified fraction from the cmde venom of Agkistrodon rhodostoma (48). The action of this venom fraction is selectively specific for fibrinogen and can rapidly deplete fibrinogen in vivo safely from the ckculating blood. Blood without fibrinogen cannot undergo clot formation. 

Fibrinolytic effecting protease enzyme with glycoprotein structure relative mol mass ca. 30000. Isolation from the poison secretion (venom) of Agkistrodon rhodostoma (malayan pit viper) with chromatographic purification. 

Zhao, H.Y., et al. 2002. Effect of electroporation and iontophoresis on skin permeation of Defi-brase—a purified thrombin-like enzyme from the venom of Agkistrodon halys ussuriensis Emelia-nov. Pharmazie 57 482. 

Venom of the Malayan pit-viper Agkistrodon rhodostoma Triethylaminoethyl cellulose powder (Serva) tris(Hydroxymethyl)aminomethane... 

Kato, H. and Suzuki, T. 1971. Bradykinin-potentiating peptides from the venom of Agkistrodon halysblomhojfii. Isolation of five bradykinin potentiators and the amino acid sequences of two of them, potentiators B and C. Biochemistry 10, 972—980. 

Anticoagulant thrombin-like enzyme found in venom of Malayan pit viper, Agkistrodon rhodostoma. 

Zinc is also found in purified hemorrhagic toxins and proteolytic enzymes from venoms. Fibrinogenase is a proteolytic enzyme which renders fibrinogen unclottable. This has one Zn per molecule of protein. Further examples include a peptidase from the venom of Agkistrodon... 

Constit. of the venom of the snakes Agkistrodon halys blomhoffii and Trimeresurus spp. 

The anticoagulant properties of several snake venoms have previously been reported.4 The venom of Agkistrodon acutus contains a procoagulant principle as well as an anticoagulant fraction, both of which have been purified and studied. It has recently been found that the anticoagulant factor inhibits prothrombin activation by interfering with the interaction between prothrombin and its activation factors.49... 

Retzios, A. D., and Markland, F. S. (1988). A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix Effects on various components of the human blood coagulation and fibrinolysis system. Thrombosis Res. 52 541... 

Ouyang, C., and Teng, C.-M., 1972, Purification and properties of the anticoagulant principle of Agkistrodon acutus venom, Biochim. Biophys. Acta 278 155-162. 

Teng, C. -M., and Seegers, W. H., 1981, Agkistrodon acutus snake venom inhibits prothrombinase complex formation, Thromb. Res. 23 255-263. 

Chen, J., Wu, X., Zhang, G., Jiang, M. and Hsu, K. (1981) Further purification and biochemical properties of a pre-synaptic neurotoxin from snake venom of Agkistrodon halys (Pallas). Acta Biochim. Biophys. 

STUDY ON THE ACTION MECHANISM OF HEMORRHAGINI FROM Agkistrodon acutus VENOM... 

Study on the Action Mechanism of Hemorrhagin I from Agkistrodon acutus Venom 363... 

Guan, A.L., Retzios, A.D., Henderson, G.N. and Markland, F.S., 1991, Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake Agkistrodon contortrix contor-trix). Arch. Biochem. Biophys. 289 197-207. 

Randolf, A., Chamberlain, S.H., Chu, C., Retzios, A.D., Markland, F.S. and Masiarz, F.R., 1992, Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom. Protein Science 1 590-600. 

Markland, F.S., Bookstein, J.J., and Machado, T., 1989, In vivo fibrinolytic activity of fibrolase, a metalloproteinase from the venom of Agkistrodon contortrix contortrix, Thrombos. Haemostas. 62 121. 

Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P. and Kuo, J., 1994, Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities, J Chromatog. B 662 227-243. 

Retzios, A.D., and Markland, F.S., 1990, HPLC-based two-step purification of fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Agkistrodon piscivorus conantii, Prot. Express. Purific. 1 33-39. 

Trikha, M., Schmitmeier, S. and Markland, F.S., 1994, Purification and characterization of fibrolase isoforms from venom of individual southern copperhead Agkistrodon contortrix contortrix) snakes, Toxicon 32 1521-1531. 

Xhang, Y, Chen N., Wang, L., Yang, B., Qian X., and Ma L., 1994, Separation and identification of Proteins obtained from Agkistrodon acutus snake Venom by Capillary Zone electrophoresis and laser Desorption/Ionization Mass Monitoring, Biomedical chromatography, 8, 148-150. 

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