Aerosol Solvent Extraction Systems carbon dioxide

Carbon dioxide has also been investigated for its suitability in Aerosol Solvent Extraction Systems (ASES), to generate microparticles of proteins suitable for aerosol delivery from aqueous based solutions. ... 

ASES Aerosol solvent extraction system involves spraying of a polar liquid with a substrate as fine droplets into an atmosphere of compressed carbon dioxide causing precipitation of fine nanoparticles... 

ASES (aerosol solvent extraction system) This is the first modification of the gas antisolvent process and involves spraying the solution through an atomization nozzle as fine droplets into compressed carbon dioxide (Figure 8.4). The dissolution of the SCF into the liquid droplets is accompanied by a large volume expansion and, consequently. 

In the second method the solution is sprayed through a nozzle into compressed carbon dioxide the process is termed as precipitation with compressed antisolvent (PCA) [33] and liquid or supercritical antisolvents can be employed. In the case of continuous flow of the solution and of the antisolvent the process is termed also as aerosol solvent extraction system (ASES) [34], in the case of countercurrent flow and supercritical antisolvent precipitation (SAS) in the case of co-current flow [35]. 

SCE-based processes such as GAS process, SAS process, aerosol solvent extraction system (ASES), SEDS address low solubility of the compounds in SCCO2. In these processes, the drug, polymer, or both are dissolved in an organic solvent to form a solution. Solvents used may include dimethyl sulfoxide, N-methyl pyrrolidone, methanol, ethanol, acetone, chloroform, or isopropanol. To successfully produce ASD, the drug and polymer should exhibit limited solubility in SCF and the organic solvent should be miscible with carbon dioxide. Collection of the precipitated particles in the antisolvent is carried out in the same vessel where solvent extraction takes place. The particles are collected on a filter unit located at the bottom of the vessel. 

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