Adverse drug reactions risk factors

Other important factors for the increased risk of adverse drug reactions are polypharmacy and multimorbidity. Before adding a drug the physician should try to diagnose the condition and rule out drugs as the cause of the problem. When a drug is added the dose should be lower than in younger adults and then the dose can be titrated to a therapeutic response. 

Nguyen JK, Fonts MM, Kotabe SE, Lo E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother 2006 4(1) 36-41. 

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Hoigne R, Lawson DH, Weber E. Risk factors for adverse drug reactions — epidemiological approaches. Eur J Clin Pharmacol 1990 39 321-5. 

Carbonin P, Pahor M, Bernabei R, Sgadari A. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients J Am Geriatr Soc 1991 39 1093-9. 

Lucas GM, Chaisson RE, Moore RD (1999) Highly active antiretroviral therapy in a large urban clinic Risk factors for virologic failure and adverse drug reactions. Ann Intern Med 131 81-87. 

Adverse drug reactions are of significant concern in the pharmaceutical technology arena. Various drug and patient factors that predispose to ADRs have been identified. Reporting systems used to screen and assess ADRs facilitate the understanding of risk factors and contribute to the development of systematic improvement in the prevention of ADRs. 

Capaul R, Maibach R, Kuenzi UP, et al. Atopy, bronchial asthma and previous adverse drug reactions (ADRs) risk factors for ADRs Post Marketing Surveillance 1993 7 331. 

In a comparison of high doses (750-1000 mg/day) and low doses (125 mg every other day) of penicillamine in the treatment of early diffuse systemic sclerosis, seven of the 34 patients in the high-dose group had proteinuria (over 1 g/day) compared with only one of the 32 in the low-dose group (45). Rheumatoid arthritis is a risk factor for renal disease, and the distinction from adverse drug reactions can be difficult in these patients (SED-14, 729). 

Okwera A, Johnson JL, Vjecha MJ, Wolski K, Whalen CC, Horn D, Huebner R, Mugerwa RD, Ellner JJ. Risk factors for adverse drug reactions during thiacetazone treatment of pulmonary tuberculosis in human immunodeficiency virus infected adults. Int J Tuberc Lung Dis 1997 l(5) 441-5. 

O Brien JG, Dong BJ, Coleman RL,Gee L, Balano KB. A 5-year retrospective review of adverse drug reactions and their risk factors in human immunodeficiency virus-infected patients who were receiving intravenous pentamidine therapy for Pneumocystis carinll pneumonia. Clin Infect Dis. 1997 May 24(5) 854-9. 

Mazor Y, Koifman E, Elkin H (2013) Risk factors for serious adverse drug reactions to thiopurines in patients with Crohn s Disease. Curr Drug Saf 8 181-185... 

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