Muscle, skeletal adverse drug reactions

ADVERSE DRUG REACTIONS INVOLVING SKELETAL MUSCLE... 

Although statin-related adverse drug reactions (ADRs) can involve the kidneys, liver, or brain [14], skeletal muscle toxicity is... 

Drowsiness is the most common reaction seen with the use of skeletal muscle relaxants. Additional adverse reactions are given in die Summary Drug Table Drugp Used to Treat Musculoskeletal Disorders. Some of the adverse reactions tiiat may be seen with the administration of diazepam include drowsiness, sedation, sleepiness, letiiargy, constipation or diarrhea, bradycardia or tachycardia, and rash. 

Skeletal muscle effects In clinical trials, there was no excess of myopathy or rhabdomyolysis associated with ezetimibe compared with the relevant control arm (placebo or HMG-CoA reductase inhibitor alone). However, myopathy and rhabdomyolysis are known adverse reactions to HMG-CoA reductase inhibitors and other lipid-lowering drugs. 

Emetine, once the drug of choice for the treatment of amebiasis, despite marked cardiotoxicity, has largely been replaced by metronidazole and related compounds for this indication. Large doses of emetine can damage the heart, hver, kidneys, intestinal tract, and skeletal muscle. Allergic reactions and tumor-inducing effects have not been described. Dehydroemetine is a httle less toxic but also less effective than emetine its adverse effects are similar (SED-11, 594). 

Cyclobenzaprine is structurally closely related to the tricyclic antidepressants (see later) and therefore shares many of their adverse reactions. These include drowsiness (CNS effects), dry mouth (anticholinergic effects), and dizziness. The potential for serious interactions with MAO inhibitors also exists. Nevertheless, the drug s centrally acting skeletal muscle relaxation is useful for short-term treatment of local muscle spasms. 

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