Advances in Protein Chemistry

This chapter lists some representative examples of biochemicals and their origins, a brief indication of key techniques used in their purification, and literature references where further details may be found. Simpler low molecular weight compounds, particularly those that may have been prepared by chemical syntheses, e.g. acetic acid, glycine, will be found in Chapter 4. Only a small number of enzymes and proteins are included because of space limitations. The purification of some of the ones that have been included has been described only briefly. The reader is referred to comprehensive texts such as the Methods Enzymol (Academic Press) series which currently runs to more than 344 volumes and The Enzymes (3rd Edn, Academic Press) which runs to 22 volumes for methods of preparation and purification of proteins and enzymes. Leading referenees on proteins will be found in Advances in Protein Chemistry (59 volumes. Academic Press) and on enzymes will be found in Advances in Enzymology (72 volumes, then became Advances in Enzymology and Related Area of Molecular Biology, J Wiley Sons). The Annual Review of Biochemistry (Annual Review Inc. Patio Alto California) also is an excellent source of key references to the up-to-date information on known and new natural compounds, from small molecules, e.g. enzyme cofactors to proteins and nucleic acids. 

Adapted from Cantor, C., and Schimmel, P., 1980. Biophysical Chemistry.. San Franci.sco W.H. Freeman, and Tanford, C., 1968. Protein denatnration. Advances in Protein Chemistry 23 121-282. 

Roberts, G. C. IC, and Jardetzky, O., 1970. Nuclear magnetic re.sonance. spectro.scopy of amino acids, peptides and proteins. Advances in Protein Chemistry 24 447-545. 

Ffill, R. L., 1965. Ffydroly.sis of proteins. Advances in Protein Chemistry 20 37-107. 

Adapted from Ohtsuki, L, Maruyama, K., and Eba.shi, S., 1986. Regulatory and cyto.skeletal protein.s of vertebrate. skeletal muscle. Advances in Protein Chemistry 38 1-67. 

Weber, G. In Advances in Protein Chemistry Anson, M.L. Bailey K. ... 

Harrington, W.F. von Hippel P.H. The stricture of collagen and gelatin. Advances in Protein Chemistry, 16 (1962) 1-138. 

Mithieux SM, Weiss AS (2005) Elastin. In Parry DAD, Squire JM (eds) Fibrous proteins coiied-coiis, collagen and elastomers. Advances in protein chemistry, vol 70. Elsevier Academic, San Diego, pp 437-461... 

The first volume of Advances in Protein Chemistry appeared in 1944, near the end of the Second World War. The papers it contained were written during the height of the battles, a tour de force considering the difficulty of communications at that time. The following quotations are taken from the Preface of Volume 1 ... 

It is important to realize that the random-chain model need not imply an absence of residual structure in the unfolded population. Formative articles—many of them appearing on the pages of Advances in Protein Chemistry—recognized this fact. Kauzmann s famous review raised the central question about structure in the unfolded state (Kauzmann, 1959) ... 

Ackers, G. (1998), Deciphering the molecular code of hemoglobin allostery , in Di Cera (Ed ), Advances in Protein Chemistry, Vol. 51, Linkage Thermodynamics of Macromolecular Interactions, Academic Press, San Diego, CA, pp. 185-253... 

L. Hill, Hydrolysis of Proteins, Advances in Protein Chemistry, 20, 37 (1965). 

Asante, E. and Collinge, J. Transgenic studies of the influence of the PrP structure on TSE diseases. In Advances in Protein Chemistry. London Academic Press, 2000, pp 273-311. 

Christianson D (1991) Structural biology of zinc. In Anfinsen C, Richards F, Edsall J, Eisenberg D (eds) Advances in protein chemistry. Metalloproteins structural aspects, vol 42. Academic Press, p 281... 

In addition to the references after each Chapter, many of the articles in early editions of Annual Reviews of Biochemistry, Advances in Enzymology, Advances in Protein Chemistry, International Reviews of Cytology, Physiological Reviews, Vitamins Hormones, and other review serials, refer to specific topics considered in the text. Most of the articles we have cited give an overview of the topics. Where these are available many individual references have been omitted. 

Sanger, F. The arrangement of amino acids in proteins. Advances in Protein Chemistry 7, 1 —67 (1952). 

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