Advanced Chemistry Development chromatography

S. Ahuja, Chromatography and Separation Chemistry Advances and Developments, ACS, Washington DC, 1986. ISBN 0841209537. 

Pirkle, W. H. In Chromatography and Separation Chemistry Advances and Developments Ahuga, S., Ed. ACS Synposium Series No. 297 American Chemical Society Washington, D.C., 1986 ... 

Langer SH, Patton JE (1973) In Purnell H (ed) New developments in gas chromatography, vol 11. Advances in analytical chemistry and instrumentation. Wiley, New York... 

Liquid chromatography (LC) instrumentation is continuously being refined and improved. Advances in electronics are incorporated into pumps, system injectors, data handling, and detectors. The reader is directed to the annual reviews from PITTCON published in LC-GCMagazine or American Laboratory or the Column Liquid Chromatography Equipment and Instrument review in Analytical Chemistry for the fundamental developments in instrumentation. 

In recent years, a confluence of spectacular advances in chemistry, molecular biology, genomics, and chemical technology, and the cognate fields of spectroscopy, chromatography, and crystallography have led to the discovery and development of numerous novel therapeutic agents for the treatment of a wide spectrum of diseases. 

The development of our understanding of the chemical themes of moth sex pheromones has been directly linked to spectacular advancements in the technologies of analytical chemistry such as open tubular capillary chromatography (OTCC), combined OTCC-mass spectroscopy, and microchemical characterization techniques. 

The development of objectionable flavor compounds by oxidation has significant detrimental effects on consumer acceptability of edible oils. In the last four decades, much progress has been made in the chemistry of volatile products of lipid oxidation, mainly as a result of advances in separation techniques and analytical methodology, particularly gas chromatography-mass spectrometry. 

Chemistry and material sciences are key disciplines for the development of advanced and more specific adsorbents. The stability and reproducibility of chromatographic columns was significantly increased by the introduction of spherical instead of irregular stationary phases. Recently, another step forward was made by the development of high efficiency monolithic columns with a rather low pressure drop. Future, further improvements, which include surface activation and internal pore structures of stationary phases, should help to tailor stationary phases for certain applications. But, besides the need for more specific and efficient solid phases, their cost is often a major problem for the widespread application of preparative chromatography. 

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