Adsorption of Low- and High-Molecular Organic Compounds

Nuclear Magnetic Resonance Studies of Interfacial Phenomena 

The solubility of drugs can be improved using the corresponding salt compounds (e.g., hydrochlorides), as well as using preparations with drugs trausformed into a nanostructured state at a surface of nanostructured matrices. 

FIGURE 1.164 Interaction of to oxide nanoparticles with a globular protein and a certain number of water molecules (CharMM calculations). (Adapted from Adv. Colloid Interface ScL, 105, Gun ko, V.M., Klyueva, A.V., Levchuk, Yu.N., and Leboda, R., Photon correlation spectroscopy investigations of proteins, 201-328, 2003b. Copyright 2003, with permission from Elsevier.) 

FIGURE 1.165 Changes in (a) the free surface energy of nanosilica A-300 impregned by chloramphenicol ( H NMR), and (b) perturbation degree of surface silanols due to the chloramphenicol adsorption (FTIR). 

This value is relatively low because the molecular size of chloramphenicol allows a molecule to interact simultaneously with two to three surface SiOH groups and it also ctui shield neighboring silanols, which remain undisturbed, from other molecules. The results with respect to the concentration behavior of the oh values can be explained by a clustered adsorption of chlor2unphenicol. 

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