0-Adrenoreceptor

Similar to dihydropyridine calcium blockers, many 0-adrenoreceptor antagonists exhibit antioxidant activity. Mak and Weglinski [290] showed that the pretreatment of canine myocytic sarcolemmal membranes with 0-adrenoreceptor antagonists (propranolol, pindolol, metoprolol, atenolol, or sotalol) (Figure 29.15) inhibited superoxide-induced sarcolemmal... 

Phentolamine (87), WB 4101 (88), and the site directed alkylatiag agent, chloroethylclonidine (CEC) (89) have been traditionally used to define a -receptors. Table 6 Hsts the various catecholamines and adrenoreceptor agonists and antagonists. 

Most of the reactions applied to amines can also be transferred to alcohols (Eig. 7-5). One large group of chiral alcohols are the (i-adrenoreceptor blockers, for which a variety of derivatization agents was developed. One highly versatile reagent for the separation of (i-blockers is A-[(2-isothiocyanato)cyclohexyl]3,5-dinitrobenzoyl-amide (DDITC) [11]. Alternatively, unichiral drugs such as (3-blockers or (S)-naproxen [12] may be used in a reciprocal approach to derivatize racemic amine compounds. 

Furchgott, R. F. (1972). The classification of adrenoreceptors (adrenergic receptors) An evaluation from the standpoint of receptor theory. In Handbook of experimental pharmacology, catecholamines, Vol. 33, edited by H. Blaschko and E. Muscholl, pp. 283—335. Springer-Verlag, Berlin. 

Folkerts, G. Nijkamp, F.J., and van Oosterhout, A.M.J. (1983). Induction in guinea-pigs of airway hyperreactitivity and decreased lung beta adrenoreceptor number by 15-HPETE. Br. J. Pharmacol. 80, 597-599. 

Snyder, S.H. Faillace, L. and Weingartner, H. A new psychotropic agent Psychological and physiological effects of 2,5 demethoxy-4-ethyl amphetamine (DOET) in man. Arch Gen Psychiatry 21 95-101. 1969. Timmermans, P.B.M.W.M., and Van Zwieten, P.A. Alpha, adrenoreceptors Classification, localization mechanisms and targets for drugs. J Med Chem 25 1389-1401, 1982. 

Choi, Y. W. Rogers, J. A., The liposome as a model membrane in correlations of partitioning with a-adrenoreceptor against activities, Pharm. Res. 7, 508-512 (1990). 

K, Values for Inhibition of 125l-lodohydroxybenzylpindolol Binding to P-Adrenoreceptors in Turkey Erythrocyte... 

Naidu PS, Singh A, Kulkarni SK. D2 dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin. Indian J Exp Biol 2003 41 1400-1404. 

Mallick, B. N., Jha, S. K Islam, F. (2002a). Presence of alpha-1 adrenoreceptors on thermosensitive neurons in the medial preoptico-anterior hypothalamic area in rats. Neuropharmacology 42, 697-705. 

Adrenoreceptors Receptors (also called adrenergic) for noradrenaline and adrenaline classified into two broad categories a and p, each comprising a number of subtypes including a1 a2, pj and p2. 

Dewar J, Wheatley A, Venn A, Morrison J, Britton J, Hall I. / -adrenoreceptor polymorphisms are in linkage disequilibrium but are not associated with asthma in an adult population. Clin Exp Allergy 1998 28 442 48. 

It is intriguing to note that the 13 SNPs reported for the / 2-adrenoreceptor gene could theoretically lead to 213 different combinations. However only 12 haplotypes were observed [57]. To date, no such a study has been reported for the / radreno-receptor gene, in which 18 polymorphisms giving rise to only 11 haplotypes are known [70]. 

O Shaughnessy KM, Fu B, Dickerson C, Thurston D, Brown MJ. The gain-of-function G389R variant of the / -adrenoreceptor does not influence blood pressure or heart rate response to /1-blockade in hypertensive subjects. Clin Science 2000 99 233-238. 

Mauriege P, Bouchard C. The Trp64Arg mutation in the / -adrenoreceptor gene of doubtful significance for obesity and insulin resistance. Lancet 1996 348 698-699. 

Podlowski S, Wenzel K, Luther HP, Muller J, Bramlage P, Baumann G, Felix SB, Speer A, Hetzer R, Kopke K, Hoehe MR, Wallukat G. / -Adrenoreceptor gene variations a role in idiopathic cardiomyopathy J Mol Med 2000 78 87-93. 

Fig. 24.6 Mutant allele frequencies of SNPs in distinct ethnic populations. B2AR-/I2 adrenoreceptor, COMT-catechol-O-methyltransferase. Glu27 and TPMT 3C allele frequencies were used for the B2AR and TPMTgenes, respectively.

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